1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. VU0364770 hydrochloride

VU0364770 hydrochloride 

Cat. No.: HY-100588A Purity: 99.82%
Handling Instructions

VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively.

For research use only. We do not sell to patients.

VU0364770 hydrochloride Chemical Structure

VU0364770 hydrochloride Chemical Structure

CAS No. : 1414842-70-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 148 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
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5 mg USD 60 In-stock
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10 mg USD 90 In-stock
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25 mg USD 110 In-stock
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50 mg USD 200 In-stock
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100 mg USD 320 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively[1].

IC50 & Target[1]

Rat mGlu4

290 nM (EC50)

Human mGlu4

1.1 μM (EC50)

mGlu6

6.8 μM (EC50)

mGlu5

17.9 μM (EC50)

Molecular Weight

269.13

Formula

C₁₂H₁₀Cl₂N₂O

CAS No.

1414842-70-8

SMILES

O=C(C1=NC=CC=C1)NC2=CC=CC(Cl)=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (371.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7157 mL 18.5784 mL 37.1568 mL
5 mM 0.7431 mL 3.7157 mL 7.4314 mL
10 mM 0.3716 mL 1.8578 mL 3.7157 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (18.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (18.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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KeyWords:

VU0364770 | VU 0364770 | VU-0364770 | mGluR | Metabotropic glutamate receptors | Inhibitor | inhibitor | inhibit

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Product name:
VU0364770 hydrochloride
Cat. No.:
HY-100588A
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