2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. A-841720

A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research.

For research use only. We do not sell to patients.

A-841720 Chemical Structure

A-841720 Chemical Structure

CAS No. : 869802-58-4

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Description

A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research[1][2].

IC50 & Target[1]

Human mGluR1

10 nM (IC50)

human mGluR5

342 nM (IC50)

Molecular Weight

343.45

Formula

C17H21N5OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(C3=C(N(C)C)C=CN=C3S2)N=CN1N4CCCCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 15 mg/mL (43.67 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9116 mL 14.5582 mL 29.1163 mL
5 mM 0.5823 mL 2.9116 mL 5.8233 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9116 mL 14.5582 mL 29.1163 mL 72.7908 mL
5 mM 0.5823 mL 2.9116 mL 5.8233 mL 14.5582 mL
10 mM 0.2912 mL 1.4558 mL 2.9116 mL 7.2791 mL
15 mM 0.1941 mL 0.9705 mL 1.9411 mL 4.8527 mL
20 mM 0.1456 mL 0.7279 mL 1.4558 mL 3.6395 mL
25 mM 0.1165 mL 0.5823 mL 1.1647 mL 2.9116 mL
30 mM 0.0971 mL 0.4853 mL 0.9705 mL 2.4264 mL
40 mM 0.0728 mL 0.3640 mL 0.7279 mL 1.8198 mL
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A-841720 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-841720869802-58-4A841720A 841720mGluRMetabotropic glutamate receptorsmGlu1 receptorchronic painInhibitorinhibitorinhibit

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