2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0404251

VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis.

For research use only. We do not sell to patients.

VU0404251

VU0404251 Chemical Structure

CAS No. : 1276013-77-4

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VU0404251 Related Antibodies

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Description

VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
7.2 nM
Compound: 8v, VU0404251
Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization
Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization
[PMID: 22981332]
HEK293 EC50
70 nM
Compound: 8v, VU0404251
Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization
Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization
[PMID: 22981332]
Molecular Weight

330.40

Formula

C19H23FN2O2
CAS No.
SMILES

O=C(N[C@H](C)C(C)(C)C)C1=CC=C(N=C1)OCC2=CC=CC(F)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU0404251 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU04042511276013-77-4VU 0404251VU-0404251mGluRMetabotropic glutamate receptorsmGlu positive allosteric modulatorInhibitorinhibitorinhibit

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