1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. LY2812223

LY2812223 

Cat. No.: HY-18760 Purity: >98.0%
Handling Instructions

LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).

For research use only. We do not sell to patients.

LY2812223 Chemical Structure

LY2812223 Chemical Structure

CAS No. : 1311385-20-2

Size Price Stock Quantity
1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg USD 700 Get quote
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively)[1].

IC50 & Target[1]

mGluR2

144 nM (Ki)

mGluR3

156 nM (Ki)

Molecular Weight

284.29

Formula

C₁₀H₁₂N₄O₄S

CAS No.

1311385-20-2

SMILES

[H][[email protected]]1(C(O)=O)[[email protected]]([[email protected]]1([H])[[email protected]](N)(C(O)=O)C2)([H])[[email protected]@H]2SC3=NN=CN3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 28.75 mg/mL (101.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5175 mL 17.5877 mL 35.1753 mL
5 mM 0.7035 mL 3.5175 mL 7.0351 mL
10 mM 0.3518 mL 1.7588 mL 3.5175 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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LY2812223
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HY-18760
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