VU6043653
Based on 1 Customer Validation
VU6043653 is a potent, selective and cross the blood-brain barrier metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 value of 325 nM for h mGlu5.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 3032791-06-0
- Formula: C16H14FN5O2
- Molecular Weight:327.31
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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human mGluR5 325 nM (IC50) |
Chemical Information
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CAS No. 3032791-06-0
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Appearance Solid
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Molecular Weight 327.31
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Formula C16H14FN5O2
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Color Off-white to light yellow
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SMILES
CC1=NC(C(NC2=CC=C(F)C=N2)=O)=CC(OC3=CN(C)N=C3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 25 mg/mL (76.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0552 mL | 15.2760 mL | 30.5521 mL | 76.3802 mL |
| 5 mM | 0.6110 mL | 3.0552 mL | 6.1104 mL | 15.2760 mL | |
| 10 mM | 0.3055 mL | 1.5276 mL | 3.0552 mL | 7.6380 mL | |
| 15 mM | 0.2037 mL | 1.0184 mL | 2.0368 mL | 5.0920 mL | |
| 20 mM | 0.1528 mL | 0.7638 mL | 1.5276 mL | 3.8190 mL | |
| 25 mM | 0.1222 mL | 0.6110 mL | 1.2221 mL | 3.0552 mL | |
| 30 mM | 0.1018 mL | 0.5092 mL | 1.0184 mL | 2.5460 mL | |
| 40 mM | 0.0764 mL | 0.3819 mL | 0.7638 mL | 1.9095 mL | |
| 50 mM | 0.0611 mL | 0.3055 mL | 0.6110 mL | 1.5276 mL | |
| 60 mM | 0.0509 mL | 0.2546 mL | 0.5092 mL | 1.2730 mL |
VU6043653 Related Classifications
HY-169345 Related Classifications
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