2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0092273

VU0092273 is a potent mGlu5 positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC50 of 0.27 μM.

For research use only. We do not sell to patients.

VU0092273

VU0092273 Chemical Structure

CAS No. : 393110-43-5

Size Price Stock Quantity
Powder + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Powder
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

VU0092273 Related Antibodies

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

VU0092273 is a potent mGlu5 positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC50 of 0.27 μM[1][2].

IC50 & Target[1]

mGlu5

0.27 μM (EC50)

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
0.27 μM
Compound: 3, VU0092273
Positive allosteric modulation of rat mGlu5 expressed in HEK293 cells in presence of glutamate EC20 concentration by Fluo-2AM dye based fluorescence analysis
Positive allosteric modulation of rat mGlu5 expressed in HEK293 cells in presence of glutamate EC20 concentration by Fluo-2AM dye based fluorescence analysis
[PMID: 22607673]
Molecular Weight

305.37

Formula

C20H19NO2
CAS No.
Appearance

Powder

Color

off-white

SMILES

O=C(N1CCC(O)CC1)C2=CC=C(C#CC3=CC=CC=C3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (163.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2747 mL 16.3736 mL 32.7472 mL
5 mM 0.6549 mL 3.2747 mL 6.5494 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2747 mL 16.3736 mL 32.7472 mL 81.8679 mL
5 mM 0.6549 mL 3.2747 mL 6.5494 mL 16.3736 mL
10 mM 0.3275 mL 1.6374 mL 3.2747 mL 8.1868 mL
15 mM 0.2183 mL 1.0916 mL 2.1831 mL 5.4579 mL
20 mM 0.1637 mL 0.8187 mL 1.6374 mL 4.0934 mL
25 mM 0.1310 mL 0.6549 mL 1.3099 mL 3.2747 mL
30 mM 0.1092 mL 0.5458 mL 1.0916 mL 2.7289 mL
40 mM 0.0819 mL 0.4093 mL 0.8187 mL 2.0467 mL
50 mM 0.0655 mL 0.3275 mL 0.6549 mL 1.6374 mL
60 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.3645 mL
80 mM 0.0409 mL 0.2047 mL 0.4093 mL 1.0233 mL
100 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.8187 mL
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VU0092273 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU0092273393110-43-5VU 0092273VU-0092273mGluRMetabotropic glutamate receptorsglutamate receptorNAMmGlu5,Inhibitorinhibitorinhibit

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