VU0410425
VU0410425 is an mGlu1 negative allosteric modulator. VU0410425 exhibits potent inhibitory activity for rat mGlu1 with an IC50 value of 140 nM. VU0410425 can be used for the research of central nervous system disorders.
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- CAS No.: 1341167-72-3
- 화학식: C19H16ClN3O3
- 분자량:369.80
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 140 nM (rat mGlu1)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
140 nM
Compound: 7; VU0410425
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Negative allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis
Negative allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM dye based fluorescence analysis
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[PMID: 26426481] |
In Vitro
VU0410425 exhibits potent inhibitory activity for rat mGlu1 with an IC50 value of 140 nM, but inactive for human mGlu1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1341167-72-3
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분자량 369.80
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화학식 C19H16ClN3O3
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SMILES
O=C(C1=NC=CC=C1)NC2=CC=C(N3C(C4C(C)(C)C4C3=O)=O)C(Cl)=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU0410425 Related Classifications
HY-120428 Related Classifications
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