2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. ML353

ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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ML353 Chemical Structure

ML353 Chemical Structure

CAS No. : 2990506-75-5

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Based on 1 publication(s) in Google Scholar

ML353 Related Antibodies

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Description

ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker[1]. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

mGlu5

18.2 nM (Ki)

In Vitro

ML353 is a fully soluble compound with a solubility of 16.9 µM or 6.0 µg/mL in PBS (PH=7.4)[1].
ML353 has excellent stability in PBS buffer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ML353 Related Antibodies
Molecular Weight

306.33

Formula

C19H15FN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC=C(C#CC2=CC(F)=CC=C2)C=C1)N(C3)CC4C3C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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ML353 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML3532990506-75-5ML 353ML-353mGluRMetabotropic glutamate receptorsSAMSolubilityStabilityInhibitorinhibitorinhibit

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