1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. RO0711401

RO0711401 

Cat. No.: HY-124419
Handling Instructions

RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.

For research use only. We do not sell to patients.

RO0711401 Chemical Structure

RO0711401 Chemical Structure

CAS No. : 714971-87-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM[1][2].

IC50 & Target[1][2]

mGluR1

56 nM (EC50)

In Vivo

RO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days[1].
Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spinocerebellar ataxia type 1 (SCA1) mice (30-week old)[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; once
Result: Caused a prolonged improvement of motor performance on the rotarod and the paw-print tests.
Molecular Weight

360.29

Formula

C₁₈H₁₁F₃N₂O₃

CAS No.
SMILES

O=C(NC1=NC(C(F)(F)F)=CO1)C2C3=C(C=CC=C3)OC4=C2C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7755 mL 13.8777 mL 27.7554 mL
5 mM 0.5551 mL 2.7755 mL 5.5511 mL
10 mM 0.2776 mL 1.3878 mL 2.7755 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RO0711401RO 0711401RO-0711401mGluRMetabotropic glutamate receptorsmGlu1PAMoralInhibitorinhibitorinhibit

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RO0711401
Cat. No.:
HY-124419
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