714971-87-6
714971-87-6
Chemical Structure
RO0711401
- CAS No.: 714971-87-6
- Formula:C18H11F3N2O3
- Molecular Weight:360.29
IUPAC Name: N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide
InChIKey: GSGDLBUOSWGZER-UHFFFAOYSA-N
SMILES: O=C(NC1=NC(C(F)(F)F)=CO1)C2C3=C(C=CC=C3)OC4=C2C=CC=C4
Biological Activity: RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RO0711401 | 99.35% | RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-Y0447RXanthenecarboxylic acid (Standard) -
Similarity Score 0.58
HY-107506Ro 67-4853 -
Similarity Score 0.57
HY-78996Methyl 9H-xanthene-9-carboxylate -
Similarity Score 0.53
HY-129136TUG-1387 -
Similarity Score 0.53
HY-B1689AMethantheline bromide -
Similarity Score 0.52
HY-B1188RPropantheline bromide (Standard) -
Similarity Score 0.52
HY-182480Trantheline bromide -
Similarity Score 0.52
HY-116701A 274 -
Similarity Score 0.51
HY-B1188SPropantheline-d3 bromide -
Explore the MedChemAI to find more analogs
References
- [1]. Serena Notartomaso, et al. Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1. Mol Brain. 2013 Nov 19;6:48. [Content Brief]
- [2]. Eric Vieira, et al. Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1666-9. [Content Brief]
