1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. VU6012962

VU6012962 

Cat. No.: HY-114403 Purity: 99.92%
Handling Instructions

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM.

For research use only. We do not sell to patients.

VU6012962 Chemical Structure

VU6012962 Chemical Structure

CAS No. : 2313526-86-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM[1].

IC50 & Target[1]

mGlu7

347 nM (IC50)

In Vitro

VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6J male mice (8 weeks old)[1]
Dosage: 1, 3, and 10 mg/kg
Administration: I.p. injections; 60 minutes prior to testing
Result: Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.
Molecular Weight

448.40

Formula

C₂₁H₁₉F₃N₄O₄

CAS No.

2313526-86-0

SMILES

O=C(C1=CC=C(OCC2CC2)C(OC)=C1)NC3=C(N4C=NC=N4)C=CC(OC(F)(F)F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (278.77 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2302 mL 11.1508 mL 22.3015 mL
5 mM 0.4460 mL 2.2302 mL 4.4603 mL
10 mM 0.2230 mL 1.1151 mL 2.2302 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.92%

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Keywords:

VU6012962VU 6012962VU-6012962mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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Product Name:
VU6012962
Cat. No.:
HY-114403
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