2. GPCR/G Protein Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  3. mGluR ERK
  4. STX107

STX107 is a metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator (NAM) with a pKi of 8.32. STX107 inhibits glutamate-induced Ca2+ mobilization, IP1 accumulation, and ERK1/2 phosphorylation. STX107 also inhibits glutamate-induced mGlu5 internalization.

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STX107

STX107 Chemical Structure

CAS No. : 935685-90-8

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STX107 Related Antibodies

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Description

STX107 is a metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator (NAM) with a pKi of 8.32. STX107 inhibits glutamate-induced Ca2+ mobilization, IP1 accumulation, and ERK1/2 phosphorylation. STX107 also inhibits glutamate-induced mGlu5 internalization[1].

IC50 & Target[1]

mGlu5

8.32 (pKi)

Clinical Trial
Molecular Weight

319.36

Formula

C18H10FN3S
CAS No.
SMILES

N#CC1=CC(F)=CC(C2=NC=C(C=C2)C#CC3=CSC(C)=N3)=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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STX107 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STX107935685-90-8STX 107STX-107mGluRERKMetabotropic glutamate receptorsExtracellular signal regulated kinasesmGlu5 receptor negative allosteric modulatoNAMCa2+ mobilizationIP1 accumulationand ERK1/2 phosphorylationInhibitorinhibitorinhibit

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