935685-90-8
935685-90-8
Chemical Structure
STX107
- CAS No.: 935685-90-8
- Formula:C18H10FN3S
- Molecular Weight:319.36
IUPAC Name: 3-fluoro-5-(5-((2-methylthiazol-4-yl)ethynyl)pyridin-2-yl)benzonitrile
InChIKey: SYOSUEIMOYEGKU-UHFFFAOYSA-N
SMILES: N#CC1=CC(F)=CC(C2=NC=C(C=C2)C#CC3=CSC(C)=N3)=C1
Biological Activity: STX107 is a metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator (NAM) with a pKi of 8.32. STX107 inhibits glutamate-induced Ca2+ mobilization, IP1 accumulation, and ERK1/2 phosphorylation. STX107 also inhibits glutamate-induced mGlu5 internalization[1].
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STX107 | STX107 is a metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator (NAM) with a pKi of 8.32. STX107 inhibits glutamate-induced Ca2+ mobilization, IP1 accumulation, and ERK1/2 phosphorylation. STX107 also inhibits glutamate-induced mGlu5 internalization. | |||||||||||||||||||||
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