Remeglurant
Remeglurant (MRZ-8456) acts as a selective, orally active and allosteric antagonist of the mGlu5 receptor, with an IC50 of 13 nM. Remeglurant (MRZ-8456) can be used in the research for dyskinesia in Parkinson’s disease (PD).
For research use only. We do not sell to patients.
- CAS No.: 1309783-00-3
- Formula: C17H15BrN4O
- Molecular Weight:371.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mGluR 5 13 nM (IC50) |
Chemical Information
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CAS No. 1309783-00-3
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Molecular Weight 371.23
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Formula C17H15BrN4O
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SMILES
O=C(N1[C@@H](C2=C(CC1)C=CC=C2)C)C3=NN4C=C(C=NC4=C3)Br
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Synonyms
MRZ-8456
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pamela R Westmark, et al. Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056. Neurobiol Dis. 2018 Nov:119:190-198. [Content Brief]
[2]. Philippe Huot, et al. Targeting metabotropic glutamate receptors for the treatment of Parkinson's disease. Neurodegener Dis Manag. 2023 Aug;13(4):203-206. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Remeglurant Related Classifications
HY-118238 Related Classifications
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