1309783-00-3
1309783-00-3
Chemical Structure
Remeglurant
Synonym(s): MRZ-8456
- CAS No.: 1309783-00-3
- Formula:C17H15BrN4O
- Molecular Weight:371.23
IUPAC Name: (R)-(6-bromopyrazolo[1,5-a]pyrimidin-2-yl)(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone
InChIKey: TUYZYSNXXSTKQX-LLVKDONJSA-N
SMILES: O=C(N1[C@@H](C2=C(CC1)C=CC=C2)C)C3=NN4C=C(C=NC4=C3)Br
Biological Activity: Remeglurant (MRZ-8456) acts as a selective, orally active and allosteric antagonist of the mGlu5 receptor, with an IC50 of 13 nM. Remeglurant (MRZ-8456) can be used in the research for dyskinesia in Parkinson’s disease (PD)[1][2].
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Remeglurant | Remeglurant (MRZ-8456) acts as a selective, orally active and allosteric antagonist of the mGlu5 receptor, with an IC50 of 13 nM. Remeglurant (MRZ-8456) can be used in the research for dyskinesia in Parkinson’s disease (PD). | |||||||||||||||||||||
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References
- [1]. Pamela R Westmark, et al. Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056. Neurobiol Dis. 2018 Nov:119:190-198. [Content Brief]
- [2]. Philippe Huot, et al. Targeting metabotropic glutamate receptors for the treatment of Parkinson's disease. Neurodegener Dis Manag. 2023 Aug;13(4):203-206. [Content Brief]
Keywords
