Metabotropic Glutamate Receptor 3 Antibody (YA4275)

Cat. No.: HY-P84578: Data Sheet COA
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Metabotropic Glutamate Receptor 3 Antibody (YA4275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Verification Image
Background
Documentation

Description

Metabotropic Glutamate Receptor 3 Antibody (YA4275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 99 kDa;

Observed band size: 330 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q14832

Gene ID

2913 [NCBI]

Immunogen

Purified recombinant fragment of human GRM3 (AA: extra 433-576) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Verification Image

Flow cytometric analysis of 1X10⁶ HeLa cells labeling Metabotropic Glutamate Receptor 3 Antibody (HY-P84578, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/50 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti- Mouse IgG H&L (HY-P8005) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Mouse IgG Isotype Control (HY-P80757, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

Background

Function：G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity

Subcellular Localization：Cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala

Isoforms & Post-Translational Modification：Q14832 has 2 isomers: Q14832-1: 98879 Da (predicted); Q14832-2: 60749 Da (predicted).

Subunit：Interacts with TAMALIN

RRID

AB_3718938

Synonyms

GLUR3; mGlu3; GPRC1C; MGLUR3

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)