SIB-1757 (Standard)
SIB-1757 (Standard) is the analytical standard of SIB-1757 (HY-102095). This product is intended for research and analytical applications. SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 31993-01-8
- Formule: C12H11N3O
- Masse moléculaire:213.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-102095
SIB-1757mGluR5 antagonist -
HY-14609A
MPEPmGlu5 Receptor Antagonist -
HY-W015546
β-N-methylamino-L-alanine hydrochlorideNeurotoxin -
HY-14609
MPEP HydrochloridemGlu5 Receptor Antagonist -
HY-100786
DL-AP3mGluR1 Antagonist -
HY-100804
L-Cysteinesulfinic acidmGluR Agonist -
HY-11095
NPS 2390CaSR/mGluR1/5 Allosteric Antagonist -
HY-100804R
L-Cysteinesulfinic acid (Standard)mGluR Agonist -
HY-100403
Ro 67-7476mGluR1 PAM -
HY-101356
CPCCOEtmGluR1b Antagonist -
HY-103558
LY379268mGlu2/3R Agonist -
HY-103568
YM-298198 hydrochloridemGluR1 Antagonist
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 31993-01-8
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Masse moléculaire 213.24
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Formule C12H11N3O
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SMILES
OC1=CC=C(C)N=C1/N=N/C2=CC=CC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Varney MA, et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81. [Content Brief]
[2]. Storto M, et al. Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. J Hepatol. 2003 Feb;38(2):179-87. [Content Brief]
[3]. Dogrul A, et al. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neurosci Lett. 2000 Oct 6;292(2):115-8. [Content Brief]
[4]. Bonsi P, et al. Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons. Neuropharmacology. 2005;49 Suppl 1:104-13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIB-1757 (Standard) Related Classifications
HY-102095R Related Classifications
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