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Cat. No.: HY-107509R

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LY2389575 hydrochloride (Standard)

LY2389575 hydrochloride (Standard) is the analytical standard of LY2389575 (hydrochloride) (HY-107509). This product is intended for research and analytical applications. LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC₅₀ value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 885104-09-6
Formula: C₁₅H₁₆BrCl₃N₄
Molecular Weight:438.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LY2389575 hydrochloride (Standard) Chemical Structure

CAS No.: 885104-09-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All mGluR Isoforms :

Chemical Information

CAS No. 885104-09-6
Molecular Weight 438.58
Formula C₁₅H₁₆BrCl₃N₄
SMILES

ClC1=CC=C(CN[C@@H]2CN(C3=NC=C(Br)C=N3)CC2)C(Cl)=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Caraci F, et al. Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. Mol Pharmacol. 2011 Mar;79(3):618-26. [Content Brief]

[2]. Zinni M, et al. mGlu3 receptor regulates microglial cell reactivity in neonatal rats. J Neuroinflammation. 2021 Jan 6;18(1):13. [Content Brief]

[3]. Srivastava A, et al. Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future. J Alzheimers Dis. 2020;78(4):1345-1361. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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LY2389575 hydrochloride (Standard)

All mGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LY2389575 hydrochloride (Standard) Related Classifications

HY-107509R Related Classifications