2. GPCR/G Protein Neuronal Signaling Protein Tyrosine Kinase/RTK JAK/STAT Signaling MAPK/ERK Pathway Apoptosis
  3. mGluR EGFR p38 MAPK Apoptosis
  4. LY456236 free base

LY456236 free base is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 free base can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 free base blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 free base can be used in epilepsy research.

For research use only. We do not sell to patients.

LY456236 free base

LY456236 free base Chemical Structure

CAS No. : 338738-57-1

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LY456236 free base Related Antibodies

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Description

LY456236 free base is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 free base can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 free base blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 free base can be used in epilepsy research[1][3].

IC50 & Target[1][2]

mGluR 1

 

EGFR

0.918 μM (IC50)

Molecular Weight

281.31

Formula

C16H15N3O2
CAS No.
SMILES

COC1=CC=C(NC2=C3C=C(OC)C=CC3=NC=N2)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY456236 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY456236338738-57-1LY 456236LY-456236mGluREGFRp38 MAPKApoptosisMetabotropic glutamate receptorsEpidermal growth factor receptorErbB-1HER1mGlu1 antagonistanticonvulsant effectskinase inhibitionvirtual kinome profilingcell proliferationMAPK signalingInhibitorinhibitorinhibit

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