Ro 64-5229
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1.
For research use only. We do not sell to patients.
- CAS No.: 246852-46-0
- Formula: C17H19Cl2N3O
- Molecular Weight:352.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
mGlu2[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.11 μM
Compound: 1a
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Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells
Inhibition of 10 uM 1S, 3R-ACPD stimulated GTP gamma 35S binding to rat mGluR2 expressed in CHO cells
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[PMID: 10465539] |
| CHO | IC50 |
500 nM
Compound: 1a
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Inhibition of [3H]-DCG IV binding on rat mGluR2 transfected cell membranes from CHO cells
Inhibition of [3H]-DCG IV binding on rat mGluR2 transfected cell membranes from CHO cells
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[PMID: 10465539] |
RO 64-5229 (50 µM) reduces the presynaptic inhibitory effect of NL1 (Neuroligin 1)[1].
RO 64-5229 (0.1, 0.3, 1 µM; 20 min) inhibits the inhibitory activity of neuroligin 1 ectodomain (Ecto-NL1; mGluR2 activator) on Forskolin (Ecto-NL1 decreases the Forskolin-induced formation of cAMP) in HEK-mGluR2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK-mGluR2 cells
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Concentration:0.1, 0.3, 1 µM
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Incubation Time:20 min
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Result:Inhibited activity of Ecto-NL1( mGluR2 activator).
Chemical Information
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CAS No. 246852-46-0
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Molecular Weight 352.26
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Formula C17H19Cl2N3O
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SMILES
ClC1=C(/C(OC2CCCCCC2)=C/N3N=CN=C3)C(Cl)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ro 64-5229 Related Classifications
HY-103557 Related Classifications
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