Metabotropic Glutamate Receptor 2 Antibody (YA4266)
(Synonyms: GLUR2; mGlu2; GPRC1B; MGLUR2)Metabotropic Glutamate Receptor 2 Antibody (YA4266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
Metabotropic Glutamate Receptor 2 Antibody (YA4266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 95/200 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 96 kDa
Purified recombinant fragment of human GRM2 (AA: extra 414-558) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Metabotropic Glutamate Receptor 2 is a Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization; (Microbial infection) Plays an important role in influenza virus internalization; (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells; (Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells[1].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Synapse; Cell projection, dendrite
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Expression
Tissue_specificity:Protein levels were detected in the cerebral cortex. It is widely expressed in different regions of the human brain and in the fetal brain. -
Subunit
Forms heterodimers with GRM3 or GRM4 (PubMed:37286794). Interacts with TAMALIN (By similarity). Interacts with HTR2A
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SwissProt ID
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Synonyms
GLUR2; mGlu2; GPRC1B; MGLUR2
Documentation
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