1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. 3,3'-Difluorobenzaldazine

3,3'-Difluorobenzaldazine (Synonyms: DFB)

Cat. No.: HY-14611
Handling Instructions

3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range.

For research use only. We do not sell to patients.

3,3'-Difluorobenzaldazine Chemical Structure

3,3'-Difluorobenzaldazine Chemical Structure

CAS No. : 15332-10-2

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Description

3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].

In Vitro

3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC50 for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies[1].

In Vivo

3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine[2].

Animal Model: Male NMRI and ICR mice (8-9 weeks, 33-40 g)[2]
Dosage: 40-100 nmol (~9.7-24.4 μg)
Administration: ICV
Result: Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
Molecular Weight

244.24

Formula

C₁₄H₁₀F₂N₂

CAS No.

15332-10-2

SMILES

FC1=CC(/C=N/N=C/C2=CC=CC(F)=C2)=CC=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

3,3'-DifluorobenzaldazineDFBmGluRMetabotropic glutamate receptorspotentiatelocomotorhyperactivityallostericmotorincoordinationcognitiveInhibitorinhibitorinhibit

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3,3'-Difluorobenzaldazine
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HY-14611
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