GRM7 Antibody (YA4274)
(Synonyms: GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87)GRM7 Antibody (YA4274) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM7.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
GRM7 Antibody (YA4274) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM7.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 102 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 102.3 kDa
Purified recombinant fragment of human GRM7 (AA: 454-590) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GRM7 is a G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits[1][2].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4 -
Isoforms & Post-Translational Modification
Q14831 has 5 isomers: Q14831-1: 102251 Da (predicted); Q14831-2: 103070 Da (predicted); Q14831-3: 101924 Da (predicted); Q14831-4: 101842 Da (predicted); Q14831-5: 101302 Da (predicted).
N-glycosylated -
Subunit
Homodimer (PubMed:33476302, PubMed:33500274). Interacts with PICK1
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SwissProt ID
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Synonyms
GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87
Documentation
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