GRM7 Antibody (YA4274)

Cat. No.: HY-P84577: Data Sheet User Guide for Antibodies
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GRM7 Antibody (YA4274) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM7.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

GRM7 Antibody (YA4274) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM7.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 102.3 kDa;

Observed band size: 102 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q14831

Gene ID

2917 [NCBI]

Immunogen

Purified recombinant fragment of human GRM7 (AA: 454-590) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604)

Subcellular Localization：Cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4

Isoforms & Post-Translational Modification：Q14831 has 5 isomers: Q14831-1: 102251 Da (predicted); Q14831-2: 103070 Da (predicted); Q14831-3: 101924 Da (predicted); Q14831-4: 101842 Da (predicted); Q14831-5: 101302 Da (predicted).
N-glycosylated

Subunit：Homodimer (PubMed:33476302, PubMed:33500274). Interacts with PICK1

Synonyms

GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87

Documentation

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/ags-cell.html [Content Brief]