GRM7 - glutamate metabotropic receptor 7 Gene

Also Known as GLUR7; MGLU7; GPRC1G; MGLUR7; NEDSHBA; PPP1R87

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2917

About GRM7

Cytogenetic location: 3p26.1 Genomic coordinates (GRCh38): 3:6,861,115-7,741,533 (from NCBI)

This gene has 15 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

GRM7 Products (8)

mRNA	Protein	Name
NM_000844.4	NP_000835.1	metabotropic glutamate receptor 7 isoform a precursor
XM_017006273.2	XP_016861762.1	metabotropic glutamate receptor 7 isoform X4
XM_047448053.1	XP_047304009.1	metabotropic glutamate receptor 7 isoform X2
XM_017006272.2	XP_016861761.1	metabotropic glutamate receptor 7 isoform X3
XR_001740135.3
XM_047448052.1	XP_047304008.1	metabotropic glutamate receptor 7 isoform X1
NM_181875.1
NM_181874.3	NP_870989.1	metabotropic glutamate receptor 7 isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adenylate cyclase inhibitor activity	IDA IDA: Inferred from direct assay	9144652	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	18599484	GOA
enables glutamate binding	IDA IDA: Inferred from direct assay	9144652	GOA
enables glutamate receptor activity	IDA IDA: Inferred from direct assay	9473604	GOA
enables group III metabotropic glutamate receptor activity	IDA IDA: Inferred from direct assay	9144652	GOA
enables protein dimerization activity	IMP IMP: Inferred from mutant phenotype	33476302	GOA
enables serine binding	IDA IDA: Inferred from direct assay	9144652	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	9473604	GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9144652	GOA
involved in axon development	IMP IMP: Inferred from mutant phenotype	33500274	GOA
NOT involved in behavioral fear response	IMP IMP: Inferred from mutant phenotype	17167337	GOA
involved in chemical synaptic transmission	IDA IDA: Inferred from direct assay	9473604	GOA
involved in glycosylation	IDA IDA: Inferred from direct assay	33500274	GOA
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	19047183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell cortex	IDA IDA: Inferred from direct assay	9630572	GOA
located in dendrite	IDA IDA: Inferred from direct assay	9630572	GOA
located in membrane	IDA IDA: Inferred from direct assay	12746871	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	33500274	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRM7 Protein Structure

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
915 a.a.

Protein Preferred Names	Protein Names
metabotropic glutamate receptor 7	glutamate receptor, metabotropic 7 protein phosphatase 1, regulatory subunit 87

GRM7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84577	GRM7 Antibody (YA4274)	ICC/IF, FC, ELISA	Human
HY-P84577A	GRM7 Antibody (YA4274)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type	Mecp2 Duplication Syndrome Lubs X-Linked Mental Retardation Syndrome MRXSL Trisomy Xq28 Mental Retardation, X-Linked, With Recurrent Respiratory Infections Intellectual Developmental Disorder, X-Linked Syndromic, Lubs Type Mental Retardation, X-Linked, Lubs Type Xlmr Syndrome, Lubs Type
Gene Duplication Disease	Gene Duplication Syndrome
Childhood Absence Epilepsy	Pyknolepsy Petit Mal Epilepsy Absence Seizures Absence Seizure Petit Mal Seizure Absence Epilepsy, Childhood Pykno-Epilepsy Epilepsy, Absence Absence Epilepsy Pycnolepsy
Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities	NEDSHBA Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Abnormalities
Deafness, Autosomal Dominant 28	DFNA28 Autosomal Dominant Nonsyndromic Deafness 28 Autosomal Dominant Deafness 28 Deafness, Autosomal Dominant, 28 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 28 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 28 Deafness, Autosomal Dominant, Type 28
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Suppression Bursts Early Infantile Epileptic Encephalopathy With Burst-Suppression Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Amyotrophic Lateral Sclerosis 19	Amyotrophic Lateral Sclerosis Type 19 ALS19 Sclerosis, Lateral, Amyotrophic, Type 19
Hypotonia
Cerebral Atrophy
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Deafness, Autosomal Dominant 64	DFNA64 Autosomal Dominant Nonsyndromic Deafness 64 Autosomal Dominant Deafness 64 Deafness, Autosomal Dominant, 64 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 64 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 64 Deafness, Autosomal Dominant, Type 64

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05837	GRM7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05838	Grm7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05839	Grm7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GRM7	MGD	MGI:1351344
Bos taurus	GRM7	VGNC	VGNC:29662
Macaca mulatta	GRM7	VGNC	VGNC:73291
Canis familiaris	GRM7	VGNC	VGNC:41514
Rattus norvegicus	GRM7	RGD	RGD:619857
Felis catus	GRM7	VGNC	VGNC:102595
Others	GRM7	NCBI