2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0477886

VU0477886 is a metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator with potent activating activity on mGlu4 (EC50 = 95nM, 89% Glu Max), good pharmacokinetic characteristics (brain: plasma Kp = 1.3), and significant therapeutic efficacy in Parkinson's disease models.

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VU0477886

VU0477886 Chemical Structure

CAS No. : 1926222-30-1

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VU0477886 Related Antibodies

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Description

VU0477886 is a metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator with potent activating activity on mGlu4 (EC50 = 95nM, 89% Glu Max), good pharmacokinetic characteristics (brain: plasma Kp = 1.3), and significant therapeutic efficacy in Parkinson's disease models.

Cellular Effect
Cell Line Type Value Description References
CHO EC50
0.095 nM
Compound: 17a; VU0477886
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay
[PMID: 27131990]
Molecular Weight

392.80

Formula

C20H13ClN4O3
CAS No.
SMILES

O=C(C1=NC=CC=C1N)NC2=CC=C(N3C(C4=C(C3=O)C=CC=C4)=O)C(Cl)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU0477886 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU04778861926222-30-1VU 0477886VU-0477886mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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