1926222-30-1

VU0477886 Chemical Structure
1926222-30-1

Chemical Structure

VU0477886

  • No. CAS: 1926222-30-1
  • Formula:C20H13ClN4O3
  • Molecular Weight:392.80

IUPAC Name: 3-amino-N-(3-chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)picolinamide

InChIKey: XBKGMJNNALFSAJ-UHFFFAOYSA-N

SMILES: O=C(C1=NC=CC=C1N)NC2=CC=C(N3C(C4=C(C3=O)C=CC=C4)=O)C(Cl)=C2

Biological Activity: VU0477886 is a metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator with potent activating activity on mGlu4 (EC50 = 95nM, 89% Glu Max), good pharmacokinetic characteristics (brain: plasma Kp = 1.3), and significant therapeutic efficacy in Parkinson's disease models.

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HY-115796 		VU0477886 VU0477886 is a metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator with potent activating activity on mGlu4 (EC50 = 95nM, 89% Glu Max), good pharmacokinetic characteristics (brain: plasma Kp = 1.3), and significant therapeutic efficacy in Parkinson's disease models.
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