1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. LY2979165

LY2979165 

Cat. No.: HY-13239 Purity: ≥98.0%
Handling Instructions

LY2979165 is the alanine prodrug of 2812223, a selective and potent orthosteric mGlu2 receptor agonist.

For research use only. We do not sell to patients.

LY2979165 Chemical Structure

LY2979165 Chemical Structure

CAS No. : 1311385-32-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 247 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 247 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 880 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
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Description

LY2979165 is the alanine prodrug of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1].

IC50 & Target[1]

mGlu2 Receptor

 

In Vivo

LY2979165 attenuated the ketamine-evoked BOLD phMRI signal in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

390.42

Formula

C₁₃H₂₂N₆O₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (128.07 mM)

DMSO : 1 mg/mL (2.56 mM; Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5613 mL 12.8067 mL 25.6134 mL
5 mM 0.5123 mL 2.5613 mL 5.1227 mL
10 mM 0.2561 mL 1.2807 mL 2.5613 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.1 mg/mL (0.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
LY2979165
Cat. No.:
HY-13239
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