1. GPCR/G Protein Neuronal Signaling
  2. mGluR
  3. LY2979165

LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist.

For research use only. We do not sell to patients.

LY2979165 Chemical Structure

LY2979165 Chemical Structure

CAS No. : 1311385-32-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 209 In-stock
Solution
10 mM * 1 mL in Water USD 209 In-stock
Solid
1 mg USD 85 In-stock
5 mg USD 190 In-stock
10 mg USD 290 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Top Publications Citing Use of Products
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Description

LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1].

IC50 & Target[1]

mGlu2 Receptor

 

In Vivo

LY2979165 attenuated the ketamine-evoked BOLD phMRI signal in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

390.42

Formula

C13H22N6O6S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@]12[C@](C(O)=O)(C[C@H]([C@]1([C@@H]2C(O)=O)[H])SC3=NN=CN3)NC([C@H](C)N)=O.N.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (128.07 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5613 mL 12.8067 mL 25.6134 mL
5 mM 0.5123 mL 2.5613 mL 5.1227 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.1 mg/mL (0.26 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (1.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (128.07 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5613 mL 12.8067 mL 25.6134 mL 64.0336 mL
5 mM 0.5123 mL 2.5613 mL 5.1227 mL 12.8067 mL
10 mM 0.2561 mL 1.2807 mL 2.5613 mL 6.4034 mL
15 mM 0.1708 mL 0.8538 mL 1.7076 mL 4.2689 mL
20 mM 0.1281 mL 0.6403 mL 1.2807 mL 3.2017 mL
25 mM 0.1025 mL 0.5123 mL 1.0245 mL 2.5613 mL
30 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1345 mL
40 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
50 mM 0.0512 mL 0.2561 mL 0.5123 mL 1.2807 mL
60 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL
80 mM 0.0320 mL 0.1601 mL 0.3202 mL 0.8004 mL
100 mM 0.0256 mL 0.1281 mL 0.2561 mL 0.6403 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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LY2979165 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
LY2979165
Cat. No.:
HY-13239
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