1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. LY 541850

LY 541850 

Cat. No.: HY-103551A
Handling Instructions

LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.

For research use only. We do not sell to patients.

LY 541850 Chemical Structure

LY 541850 Chemical Structure

CAS No. : 852679-76-6

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Description

LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively[1].

IC50 & Target[1]

mGluR2

0.161 μM (IC50)

mGluR3

1.05 μM (IC50)

In Vivo

LY 541850 (intraperitoneal injection; 10 mg/kg-300 mg/kg; 15 min prior) induces a concentration-dependent inhibition of the TAP evoked fEPSPs in CA1-SLM in 10-16 week old (EC50 42 nM) in CD-1 mice[1].
LY 541850 (intraperitoneal injection; 10 mg/kg-300 mg/kg; 30 min prior) reduces the increased locomotor activity of phencyclidine and amphetamine in a dose-dependent manner in male ICR mice[1].

Molecular Weight

199.20

Formula

C₉H₁₃NO₄

CAS No.

852679-76-6

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LY 541850
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HY-103551A
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