Metabotropic glutamate receptor 5 Antibody (YA4007)
(Synonyms: mGlu5; GPRC1E; MGLUR5; PPP1R86)Metabotropic glutamate receptor 5 Antibody (YA4007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic glutamate receptor 5.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
IHC-P, ICC/IF, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS with 0.05% sodium azide
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:10000 |
Product Details
Metabotropic glutamate receptor 5 Antibody (YA4007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic glutamate receptor 5.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 132 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 132 kDa
Purified recombinant fragment of human GRM5 (AA: extra 458-580) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS with 0.05% sodium azide
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Metabotropic glutamate receptor 5 is a G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity
-
Subcellular Localization
Cell membrane; Multi-pass membrane protein
-
Isoforms & Post-Translational Modification
P41594 has 3 isomers: P41594-1: 132469 Da (predicted); P41594-2: 128874 Da (predicted); P41594-3: 105432 Da (predicted).
-
Subunit
The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Isoform 2 interacts with NECAB2 (PubMed:19694902). Interacts with CAMK2A (PubMed:28130356)
-
SwissProt ID
-
Synonyms
mGlu5; GPRC1E; MGLUR5; PPP1R86
Documentation
Powered by Bioz
