GRM5 - glutamate metabotropic receptor 5 Gene

Also Known as mGlu5; GPRC1E; MGLUR5; PPP1R86

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2915

About GRM5

Cytogenetic location: 11q14.2-q14.3 Genomic coordinates (GRCh38): 11:88,504,642-89,065,982 (from NCBI)

This gene has 5 transcripts (splice variants), 270 orthologues and 7 paralogues. Restricted expression toward brain (RPKM 10.2).

Summary

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GRM5 Products (4)

mRNA	Protein	Name
NM_001384268.1	NP_001371197.1	metabotropic glutamate receptor 5 isoform b precursor
NM_000842.5	NP_000833.1	metabotropic glutamate receptor 5 isoform b precursor
NM_001143831.3	NP_001137303.1	metabotropic glutamate receptor 5 isoform a precursor
XM_011542792.2	XP_011541094.1	metabotropic glutamate receptor 5 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	7908515	GOA
enables glutamate receptor activity	IDA IDA: Inferred from direct assay	7908515	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	30675062	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19694902	GOA
enables protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	24012003	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	7908515	GOA
involved in cellular response to amyloid-beta	IGI IGI: Inferred from genetic interaction	24012003	GOA
involved in cognition	IMP IMP: Inferred from mutant phenotype	23227193	GOA
involved in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	24012003	GOA
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	24012003	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in dendrite	IDA IDA: Inferred from direct assay	24012003	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	7908515	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRM5 Protein Structure

ANF_receptor

NCD3G

7tm_3

GluR_Homer-bdg

0
200
400
600
800
1000
1212 a.a.

Protein Preferred Names	Protein Names
metabotropic glutamate receptor 5	glutamate receptor, metabotropic 5 protein phosphatase 1, regulatory subunit 86

GRM5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GRM5	P41594	NECAB2	Homo sapiens	Q7Z6G3-2	Anti Tag CoIP	19694902
Intra	GRM5	P41594	GRM5	Homo sapiens	P41594	X-Ray Diffraction	30675062
Intra	GRM5	P41594	GRM5	Homo sapiens	P41594	3D-EM	30675062
Intra	GRM5	P41594	NECAB2	Homo sapiens	Q7Z6G3-1	Anti Tag CoIP	19694902
Intra	GRM5	P41594	PRKCZ	Homo sapiens	Q05513	PLA	25241761

Cross: Cross-species interaction Intra: Intraspecies interaction

GRM5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80220	Metabotropic glutamate receptor 5 Antibody (YA297)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
HY-P81764	Metabotropic glutamate receptor 5 Antibody (YA1509)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P84310	Metabotropic glutamate receptor 5 Antibody (YA4007)	IHC-P, ICC/IF, ELISA	Human
HY-P84310A	Metabotropic glutamate receptor 5 Antibody (YA4007)(PBS only)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
X-Linked Hereditary Ataxia
Central Nervous System Disease	CNS Cns Diseases Central Nervous System Diseases Cns Disorder
Premature Ovarian Failure 1	Ovarian Failure, Premature Fmr1-Related Primary Ovarian Insufficiency Fragile X-Associated Primary Ovarian Insufficiency POF1 Pofx Hypergonadotropic Ovarian Failure, X-Linked Pof Primary Ovarian Insufficiency, Fragile X-Associated Primary Ovarian Insufficiency 1 Ovarian Failure Premature Premature Ovarian Failure, X-Linked Fragile X Premature Ovarian Failure Fmr1-Related Premature Ovarian Failure Familial Premature Ovarian Failure Idiopathic Familial Premature Ovarian Failure Fxpoi X-Linked Hypergonadotropic Ovarian Failure Hypergonadotropic Ovarian Failure X-Linked Poi Premature Ovarian Failure X-Linked Primary Ovarian Insufficiency Premature Ovarian Failure-1 Ovarian Failure, Premature, Type 1 Premature Ovarian Failure, Familial Premature Menopause Primary Hypogonadism Turner Syndrome
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Gallbladder Small Cell Carcinoma	Oat Cell Carcinoma Of The Gallbladder Gallbladder Small Cell Neuroendocrine Carcinoma
Anterograde Amnesia	Amnesia, Anterograde
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Rett Syndrome	Atypical Rett Syndrome RTT Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Atypical Rett Syndrome, Preserved Speech Variant Rett'S Disorder Rett Syndrome Variant Rett Disorder Cerebroatrophic Hyperammonemia Rett Like Syndrome Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Ganglioglioma	Childhood Ganglioglioma Adult Ganglioglioma Cns Ganglioglioma Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Specific Developmental Disorder
Substance Dependence
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
X-Linked Monogenic Disease
Status Epilepticus	Grand Mal Status Epilepticus Grand Mal Status Gcse Generalized Convulsive Status Epilepticus Se Epilepsy With Status Epilepticus
Focal Epilepsy	Partial Epilepsy Epilepsies, Partial Localisation-Related Epilepsy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Disease Of Mental Health	Mental Health Mental Disorders
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Schizophrenia 6	SCZD6 Schizophrenia Susceptibility Locus, Chromosome 8p-Related Schizophrenia, Type 6
Barre-Lieou Syndrome	Cervicocranial Syndrome Posterior Cervical Sympathetic Syndrome
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Granulomatous Angiitis	Vasculitis, Central Nervous System
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Fragile X-Associated Tremor/Ataxia Syndrome	Fxtas Syndrome Fragile X Tremor/Ataxia Syndrome Fxtas
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05831	GRM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05832	Grm5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05833	Grm5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GRM5	VGNC	VGNC:103033
Rattus norvegicus	GRM5	RGD	RGD:2746
Bos taurus	GRM5	VGNC	VGNC:56292
Mus musculus	GRM5	MGD	MGI:1351342
Macaca mulatta	GRM5	VGNC	VGNC:73289
Canis familiaris	GRM5	VGNC	VGNC:41512
Others	GRM5	NCBI