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Isoforms Recommended:	DNA gyrase

Results for "

DNA+gyrase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (1) Antibiotic (88) Apoptosis (8) Bacterial (161) Beta-lactamase (1) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA Glycosylase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (97) Drug Derivative (1) Drug Metabolite (5) Endogenous Metabolite (5) Farnesyl Transferase (1) Fungal (2) HCV (1) HCV Protease (1) HDAC (2) HSP (3) Interleukin Related (3) Isotope-Labeled Compounds (16) JAK (1) MicroRNA (5) Orthopoxvirus (15) Parasite (8) PPAR (1) Proton Pump (2) Reactive Oxygen Species (ROS) (1) Reference Standards (27) TGF-beta/Smad (2) Topoisomerase (67)
By Research Areas:	Cancer (24) Infection (166) Inflammation/Immunology (20) Metabolic Disease (1) Neurological Disease (3)

By Targets:

Aminopeptidase (1)

Antibiotic (88)

Apoptosis (8)

Bacterial (161)

Beta-lactamase (1)

Cytochrome P450 (1)

Dihydrofolate reductase (DHFR) (1)

DNA Glycosylase (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (97)

Drug Derivative (1)

Drug Metabolite (5)

Endogenous Metabolite (5)

Farnesyl Transferase (1)

Fungal (2)

HCV (1)

HCV Protease (1)

HDAC (2)

HSP (3)

Interleukin Related (3)

Isotope-Labeled Compounds (16)

JAK (1)

MicroRNA (5)

Orthopoxvirus (15)

Parasite (8)

PPAR (1)

Proton Pump (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (27)

TGF-beta/Smad (2)

Topoisomerase (67)

By Research Areas:

Cancer (24)

Infection (166)

Inflammation/Immunology (20)

Metabolic Disease (1)

Neurological Disease (3)

174

Inhibitors & Agonists

Peptides

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Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0330

Levofloxacin Maximum Cited Publications 35 Publications Verification (-)-Ofloxacin	Topoisomerase DNA/RNA Synthesis Antibiotic Bacterial Orthopoxvirus	Infection Cancer
Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the *DNA gyrase* and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity .

HY-B0425

Novobiocin 10+ Cited Publications Albamycin; Cathomycin	Antibiotic DNA/RNA Synthesis HSP Apoptosis Bacterial Orthopoxvirus	Infection Cancer
Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a *DNA gyrase* inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity .

HY-B0425A

Novobiocin sodium 10+ Cited Publications Albamycin sodium; Cathomycin sodium	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP	Infection Cancer
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a *DNA gyrase* inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-N2033

Chebulinic acid 3 Publications Verification	DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Infection
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-B0125

Ofloxacin 10+ Cited Publications Hoe-280	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection Cancer
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-N7452

Coumermycin A1 Maximum Cited Publications 27 Publications Verification	JAK Bacterial Orthopoxvirus	Metabolic Disease
Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits *DNA Gyrase* which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.

HY-B0398

Nalidixic acid 2 Publications Verification	Bacterial Antibiotic Topoisomerase	Infection
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of *DNA gyrase* and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-B0330A

Levofloxacin hydrate Maximum Cited Publications 35 Publications Verification Levofloxacin hemihydrate	Bacterial Antibiotic Topoisomerase DNA/RNA Synthesis Orthopoxvirus	Infection Cancer
Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the *DNA gyrase* and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity .

HY-B0132

Norfloxacin 5 Publications Verification MK-0366	Bacterial Endogenous Metabolite Antibiotic	Infection
Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

HY-17647

Zoliflodacin 5+ Cited Publications ETX0914; AZD0914	DNA/RNA Synthesis Bacterial Antibiotic	Infection
Zoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC₉₀ of 0.25 μg/mL.

HY-B0398A

Nalidixic acid sodium salt 2 Publications Verification	Bacterial Antibiotic Topoisomerase	Infection
Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of *DNA gyrase* and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-W011117

Danofloxacin	Bacterial DNA/RNA Synthesis Antibiotic	Infection
Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens .

HY-B1210

Pipemidic acid 1 Publications Verification	Bacterial Antibiotic	Infection
Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections .

HY-N7066

Difloxacin hydrochloride A-56619 hydrochloride	Bacterial DNA/RNA Synthesis	Infection
Difloxacin hydrochloride (A-56619 hydrochloride) is an orally active bactericidal agent. Difloxacin hydrochloride inhibits bacterial *DNA gyrase. Difloxacin hydrochloride exhibits concentration-dependent bactericidal activity. Difloxacin hydrochloride shows strong in vitro activity against a variety of Gram-positive and Gram-negative bacteria. Difloxacin hydrochloride can be used in research related to colibacillosis and Staphylococcus aureus* infections .

HY-B0330S

Levofloxacin-d8 (-)-Ofloxacin-d₈	Bacterial Antibiotic	Infection
Levofloxacin-d₈ is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

HY-B0132S

Norfloxacin-d5	Bacterial Antibiotic	Infection
Norfloxacin-d₅ is the deuterium labeled Norfloxacin. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase .

HY-16742B

Gepotidacin mesylate hydrate 10+ Cited Publications	Antibiotic Bacterial Topoisomerase	Infection
Gepotidacin mesylate hydrate is an orally active triazaacenaphthylene antibiotic and bacterial type II topoisomerase inhibitor. Gepotidacin mesylate hydrate inhibits bacterial DNA replication by blocking topoisomerase enzymes. Gepotidacin mesylate hydrate selectively inhibits topoisomerase IV and the B subunit of DNA gyrase .

HY-162959

BWC0977	Bacterial Topoisomerase DNA/RNA Synthesis	Infection
BWC0977 is an antibacterial agent that inhibits bacterial DNA replication via inhibition of *DNA gyrase* and topoisomerase IV. BWC0977 exhibits a minimum inhibitory concentration (MIC₉₀) of 0.03-2 µg/mL against MDR (Multi-Drug Resistant) Gram-negative bacteria .

HY-B0132R

Norfloxacin (Standard) MK-0366 (Standard)	Reference Standards Bacterial Endogenous Metabolite Antibiotic	Infection
Norfloxacin (Standard) is the analytical standard of Norfloxacin. This product is intended for research and analytical applications. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

HY-B0536

Clinafloxacin AM-1091; CI-960; PD 127391	Bacterial Antibiotic	Infection
Clinafloxacin (AM 1091) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin is against *DNA gyrase* and topoisomerase IV of?S. aureus with IC₅₀ values of 0.92 μg/ml and 1.62 μg/ml, respectively .

HY-123515

Clorobiocin		Infection
Clorobiocin is an antibacterial agent with an IC₅₀ of 0.21 μM against the B subunit of E. coli DNA gyrase. Clorobiocin targets the mLaC protein of Gram-negative bacteria. Clorobiocin potently inhibits bacterial DNA replication. Clorobiocin can be used in studies on Gram-negative bacterial infections, such as Acinetobacter baumannii and E. coli infections .

HY-135389

Desmethyl Levofloxacin	Drug Metabolite Antibiotic	Infection
Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial *DNA gyrase*, halting DNA replication .

HY-B0125R

Ofloxacin (Standard) Hoe-280 (Standard)	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-175539

DNA gyrase/Topo IV-IN-2	Bacterial Topoisomerase DNA/RNA Synthesis	Infection
DNA gyrase/Topo IV-IN-2 (Compound AK19) is an antibacterial agent with IC₅₀ values of 0.783 μM and 7.136 μM against E. coli *DNA gyrase* and topoisomerase IV, respectively. DNA gyrase/Topo IV-IN-2 exhibits broad-spectrum antibacterial efficacy against both Gram-positive and Gram-negative pathogens. DNA gyrase/Topo IV-IN-2 can inhibit the biofilms of B. subtilis and MRSA, with an MIC of 1.9 μM against both B. subtilis and MRSA. DNA gyrase/Topo IV-IN-2 can be used in research related to anti-drug-resistant bacterial drugs .

HY-W013766

Pipemidic acid trihydrate 1 Publications Verification	Bacterial Antibiotic	Infection
Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections .

HY-B0536A

Clinafloxacin hydrochloride AM 1091 hydrochloride; CI 960 hydrochloride; PD127391 hydrochloride	Bacterial Antibiotic	Infection
Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro . Clinafloxacin hydrochloride is against *DNA gyrase* and topoisomerase IV of S. aureus with IC₅₀ values of 0.92 µg/ml and 1.62 µg/ml, respectively .

HY-149851

DNA Gyrase-IN-7	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-7 (compound 6d) is a novel Microbial DNA-Gyrase inhibitor .

HY-147945

DNA gyrase B-IN-1	DNA/RNA Synthesis Bacterial	Infection
DNA gyrase B-IN-1 (compound 13) is a potent DNA gyrase B inhibitor. DNA gyrase B-IN-1 shows inhibition of P. aeruginosa DNA gyrase B, with an IC₅₀ of 2.2 μM. DNA gyrase B-IN-1 has good binding affinity and stability .

HY-149379

DNA gyrase B-IN-3	Bacterial DNA/RNA Synthesis	Infection
DNA gyrase B-IN-3 (Compound A) is a bacterial DNA gyrase B inhibitor (IC₅₀: < 10 nM). DNA gyrase B-IN-3 has antibacterial activity against gram-positive strains .

HY-147818

DNA Gyrase-IN-2	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-2 (Compound 22a) is a *bacterial DNA gyrase* B** inhibitor with IC₅₀s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity .

HY-170567

DNA gyrase/Topo IV-IN-1	Topoisomerase Bacterial Antibiotic	Infection
DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of *DNA gyrase* and topoisomerase IV, exhibiting antibacterial activity. For Escherichia coli and methicillin-resistant Staphylococcus aureus DNA gyrases, DNA gyrase/Topo IV-IN-1 has an IC₅₀ of 11 and 17 nM respectively, and for topoisomerase IV of Escherichia coli and methicillin-resistant Staphylococcus aureus, the IC₅₀ values are 83 and 21 nM respectively. DNA gyrase/Topo IV-IN-1 can be used for research in the field of anti-infection .

HY-147819

DNA Gyrase-IN-3	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-3 (Compound 28) is a *bacterial DNA gyrase* B** inhibitor with IC₅₀s of 5.41-15.64 µM for E. coli DNA gyrase. Anti-tubercular and antibacterial activity .

HY-155007

DNA gyrase B-IN-2	Bacterial	Infection
DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC₅₀ < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .

HY-168511

DNA Gyrase-IN-13	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-13 (compound 1b) is a *DNA Gyrase* inhibitor. DNA Gyrase-IN-13 has antibacterial activity. DNA Gyrase-IN-13 has an IC₅₀ value of 1.81 μM for Staphylococcus aureus DNA gyrase .

HY-125631

Cyclothialidine Ro 09-1437	DNA/RNA Synthesis Bacterial	Infection
Cyclothialidine ( Ro 09-1437) is a potent *DNA gyrase* inhibitor isolated from Streptomyces filipinensisNR0484 .

HY-149534

DNA Gyrase-IN-9	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-9 (compound 4j) is an antibacterial agent that targets DNA gyrase. The MIC to inhibit Gram bacteria is 0.5-2 μg/mL, and the MBC to kill Gram bacteria is 2-8 μg/mL. DNA Gyrase-IN-9 inhibits DNA gyrase in Staphylococcus aureus with IC₅₀=6.29 μg/mL .

HY-168648

DNA Gyrase/DHFR-IN-1	Bacterial Fungal Dihydrofolate reductase (DHFR)	Infection
DNA Gyrase/DHFR-IN-1 is a dual inhibitor of bacterial *DNA gyrase* and DHFR, with IC₅₀s of 182 μM and 3.90 μM for E. coli DNA gyrase and DHFR respectively. DNA Gyrase/DHFR-IN-1 has bactericidal and antifungal activity .

HY-B0132A

Norfloxacin hydrochloride MK-0366 hydrochloride	Bacterial Antibiotic	Infection
Norfloxacin hydrochloride (MK-0366 hydrochloride) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

HY-149294

DNA Gyrase-IN-8	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-8 is a potent *DNA gyrase* inhibitor with an IC₅₀ value of 8.45 µM. DNA Gyrase-IN-8 shows antimicrobial activity .

HY-156014

qsl-304	DNA/RNA Synthesis	Infection
qsl-304 is a DNA gyrase B inhibitor. qsl-304 is an antibacterial agent, with an IC₅₀ of 31.23 mg/mL against the Staphylococcus aureus sa-P2003 .

HY-P3473

Evybactin	Bacterial DNA/RNA Synthesis	Infection
Evybactin is a *DNA gyrase* inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity .

HY-172962

DNA Gyrase-IN-17	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-17 (Compound 5C) is a *DNA Gyrase* inhibitor. DNA Gyrase-IN-17 exhibits significant antibacterial activity against a variety of Gram-positive and Gram-negative strains (such as Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, etc.), with a MIC value of 62.5 μg/mL. DNA Gyrase-IN-17 interferes with DNA replication by inhibiting bacterial DNA gyrase. DNA Gyrase-IN-17 can be used in the development of antibacterial drugs, especially for the study of drug-resistant strains .

HY-101472

Closthioamide	Bacterial	Infection
Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against Ec, MRSA, VRE and Mv), with MICs of 9.00 μM, 0.58 μM, 0.58 μM and 72.03 μM respectively.

HY-101967

GSK299423	DNA/RNA Synthesis Bacterial	Infection
GSK 299423 is an antibiotic agent.GSK299423 shows potent inhibition of supercoiling by *DNA gyrase* from S. aureus(IC₅₀=14 nM）and Escherichia coli(IC₅₀=100 nM .

HY-B0125S1

Ofloxacin-d8	Bacterial Antibiotic	Infection
Ofloxacin-d₈ (Hoe-280-d8) is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.

HY-125117

Simocyclinone D8	DNA/RNA Synthesis Bacterial	Infection Cancer
Simocyclinone D8 is an anthracycline antibiotic with antibacterial and antitumor activity against Gram-positive bacteria. Simocyclinone D8 inhibits *DNA gyrase* and thus has an inhibitory effect on a variety of tumor cell lines .

HY-161756

DNA Gyrase-IN-10	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-10 is a potent *DNA gyrase* inhibitor with potent antibacterial effects. DNA Gyrase-IN-10 has inhibitory effects on both Gram-positive and Gram-negative bacteria .

HY-N2033R

Chebulinic acid (Standard)	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Infection
Chebulinic acid (Standard) is the analytical standard of Chebulinic acid. This product is intended for research and analytical applications. Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-147988

DNA Gyrase-IN-5	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-5 (Compound 8I-w) is a potent *DNA gyrase* inhibitor with an IC₅₀ of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains .

HY-169521

DNA Gyrase-IN-16	DNA/RNA Synthesis Bacterial	Infection
DNA Gyrase-IN-16 (Compound 9) is the inhibitor for *DNA gyrase* with an IC₅₀ of 1.609 μM. DNA Gyrase-IN-16 exhibits antibacterial activity, inhibits S. aureus and MRSA with MIC of 3.125 μM and 3.125 μM .

Cat. No.	Product Name	Target	Research Area

HY-P3473

Evybactin	Bacterial DNA/RNA Synthesis	Infection
Evybactin is a *DNA gyrase* inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0425A

Novobiocin sodium 10+ Cited Publications Albamycin sodium; Cathomycin sodium	Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP
Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a *DNA gyrase* inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .

HY-N2033

Chebulinic acid 3 Publications Verification	Infection Classification of Application Fields Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-B0125

Ofloxacin 10+ Cited Publications Hoe-280	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-N7452

Coumermycin A1 Maximum Cited Publications 27 Publications Verification	Microorganisms Antibiotics Source Classification	JAK Bacterial Orthopoxvirus
Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits *DNA Gyrase* which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.

HY-B0398

Nalidixic acid 2 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic Topoisomerase
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of *DNA gyrase* and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-B0132

Norfloxacin 5 Publications Verification MK-0366	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Bacterial Endogenous Metabolite Antibiotic
Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

HY-B0147

Pefloxacin 3 Publications Verification Pefloxacinium	Infection Classification of Application Fields Disease Research Fields	Antibiotic Bacterial Parasite DNA/RNA Synthesis Topoisomerase
Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting *DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I* with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-B0132R

Norfloxacin (Standard) MK-0366 (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Bacterial Endogenous Metabolite Antibiotic
Norfloxacin (Standard) is the analytical standard of Norfloxacin. This product is intended for research and analytical applications. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

HY-B0125R

Ofloxacin (Standard) Hoe-280 (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-N2150

Psammaplin A	Structural Classification Classification of Application Fields Marine natural products Antibacterial Disease Research Other Antibiotics Infection Microorganisms Animals Antibiotics Phenols Polyphenols Sponge Anticancer Disease Research Fields Source Classification	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial Aminopeptidase Farnesyl Transferase PPAR Apoptosis
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC₅₀: 45 nM), DNA methyltransferases (IC₅₀: 18.6 nM) and aminopeptidase N (APN) (IC₅₀: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .

HY-101472

Closthioamide	Infection Microorganisms Classification of Application Fields Antibiotics Phenols Polyphenols Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against Ec, MRSA, VRE and Mv), with MICs of 9.00 μM, 0.58 μM, 0.58 μM and 72.03 μM respectively.

HY-125117

Simocyclinone D8	Microorganisms Antibiotics Source Classification	DNA/RNA Synthesis Bacterial
Simocyclinone D8 is an anthracycline antibiotic with antibacterial and antitumor activity against Gram-positive bacteria. Simocyclinone D8 inhibits *DNA gyrase* and thus has an inhibitory effect on a variety of tumor cell lines .

HY-N2033R

Chebulinic acid (Standard)	Structural Classification Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid (Standard) is the analytical standard of Chebulinic acid. This product is intended for research and analytical applications. Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-B0398R

Nalidixic acid (Standard)	Structural Classification Microorganisms Antibiotics Resistance Selection Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic Topoisomerase
Nalidixic acid (Standard) is the analytical standard of Nalidixic acid. This product is intended for research and analytical applications. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of *DNA gyrase* and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-141442

Dihydronovobiocin	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Antibiotic
Dihydronovobiocin is a bacterial inhibitor and ATPase inhibitor that can bind to GyrB. Dihydronovobiocin can be used to study the interaction between coumarin antibiotics (such as Novobiocin, Chlorobiocin, and Coumermycin) and DNA gyrase. Dihydronovobiocin also has the potential to study bacterial infections .

HY-114604

Propioxatin B	Natural Products Microorganisms Source Classification	Bacterial
Propioxatin B is a tricyclic sesquiterpenoid compound isolated from the root of vetiver grass. It has anti-tuberculosis activity and inhibitory effects on a variety of drug-resistant mutants of Mycobacterium tuberculosis. In computer simulation docking studies, it showed binding affinity with bacterial DNA gyrase and has a certain safety in vivo.

Species:	E.coli (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701907

	gyrB Protein, E.coli (Y5S, N198D) gyrB; DNA gyrase subunit B; Type IIA topoisomerase subunit GyrB	E.coli	E. coli
	The GyrB protein negatively supercoils DNA, making it more accessible to topoisomerase 4. gyrB Protein, E.coli is the recombinant E. coli-derived gyrB protein, expressed by E. coli , with tag free.

HY-P701908

	gyrB Protein, E.coli (Y5S, N198D, His) gyrB; DNA gyrase subunit B; Type IIA topoisomerase subunit GyrB	E.coli	E. coli
	The GyrB protein negatively supercoils DNA, making it more accessible to topoisomerase 4. gyrB Protein, E.coli (Y5S, N198D, His) is the recombinant E. coli-derived gyrB protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0330S

Levofloxacin-d8
Levofloxacin-d₈ is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

HY-B0132S

Norfloxacin-d5
Norfloxacin-d₅ is the deuterium labeled Norfloxacin. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase .

HY-B0125S1

Ofloxacin-d8
Ofloxacin-d₈ (Hoe-280-d8) is the deuterium labeled Ofloxacin. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase.

HY-B0398S

Nalidixic Acid-d5

Nalidixic Acid-d₅ is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria .

HY-B0268S1

Enoxacin-d8 hydrochloride

Enoxacin-d₈ (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 μg/ml) and topoisomerase IV (IC₅₀=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-B0724BS

Pazufloxacin-d4

Pazufloxacin-d₄ is deuterium labeled Pazufloxacin (HY-B0724B). Pazufloxacin is an orally active fluoroquinolone antimicrobial agent. Pazufloxacin inhibits DNA gyrase with IC₅₀ values of 0.88 μg/mL (E. coli) and 1.9 μg/mL (P. aeruginosa). Pazufloxacin exhibits broad-spectrum antimicrobial activity, with MIC₉₀ values ranging from 0.025 to 100 μg/mL against Gram-positive and Gram-negative bacteria, non-fermenting bacteria, Legionella spp., and anaerobic bacteria. Pazufloxacin is indicated for research on systemic infections, lung infections, urinary tract infections, and Legionella pneumonia .

HY-B0330S1

(S)-Ofloxacin-d3
(S)-Ofloxacin-d₃ is the deuterium labeled Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

HY-B0132S1

Norfloxacin-d8
Norfloxacin-d₈ is the deuterium labeled Norfloxacin. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

HY-135389S

Desmethyl Levofloxacin-d8 hydrochloride
Desmethyl Levofloxacin-d8 hydrochloride is the deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial *DNA gyrase*, halting DNA replication .

HY-135389S1

Desmethyl Levofloxacin-d8
Desmethyl Levofloxacin-d₈ is deuterium labeled Desmethyl Levofloxacin. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication .

HY-W011117S

Danofloxacin-d3
Danofloxacin-d₃ is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-W011117S1

Danofloxacin-d3-1
Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

HY-B0330BS1

Levofloxacin-d3 hydrochloride

Levofloxacin-d₃ ((-)-Ofloxacin-d₃) hydrochlorideis deuterium labeled Levofloxacin (hydrochloride). Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity .

HY-W744235

Levofloxacin-d3 sodium

Levofloxacin-d₃ sodium is the deuterium labeled Levofloxacin sodium (HY-B0330C). Levofloxacin ((-)-Ofloxacin) sodium is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin sodium inhibits the DNA gyrase and topoisomerase IV. Levofloxacin sodium can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin sodium shows anti-orthopoxvirus activity .

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-B0395DS

(1R,2S,7R)-Sitafloxacin-d4 hydrochloride
(1R,2S,7R)-Sitafloxacin-d₄ hydrochloride is deuterium labeled (1R,2S,7R)-Sitafloxacin hydrochloride (HY-B0395D). (R)-Sitafloxacin (DU-6857), a stereoisomer of Sitafloxacin (DU-6859a), is also an inhibitor of topoisomerases, with an IC₅₀ of 0.18 μg/mL of DNA gyrase .

HY-W700069

Gatifloxacin-d4

Gatifloxacin-d₄ (AM-1155-d₄) is the deuterium labeled Gatifloxacin (HY-10581). Gatifloxacin (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin inhibits bacterial type II topoisomerases (IC₅₀ = 13.8 μg/mL for S. aureus topoisomerase IV) and E.coli DNA gyrase (IC₅₀ = 0.109 μg/mL) . Gatifloxacin can be used for the study of bacterial conjunctivitis in vivo.

HY-B0268S2

Enoxacin-d8 hydrate

Enoxacin-d₈ (hydrate) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC₅₀=126 μg/ml) and topoisomerase IV (IC₅₀=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing .

HY-B0147S1

Pefloxacin-d3

Pefloxacin-d₃ (Pefloxacinium-d₃) is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-B0147S

Pefloxacin-d5

Pefloxacin-d₅ (Pefloxacinium-d₅) is the deuterium labeled Pefloxacin (HY-B0147). Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC₅₀ of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC₉₀s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies .

HY-B0506S1

Nadifloxacin-d5

Nadifloxacin-d₅ (OPC7251-d₅) is deuterium labeled Nadifloxacin (HY-B0506). Nadifloxacin (OPC7251) is a broad-spectrum quinolone antibiotic. Nadifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, interfering with DNA replication. It also suppresses the production of proinflammatory cytokines (such as IL-1α, IL-6, and IL-8). Nadifloxacin exhibits antibacterial activity against various pathogens, including Propionibacterium acnes and Staphylococcus aureus. Nadifloxacin also exhibits anti-inflammatory activity. Nadifloxacin can be used in the research of skin infections such as acne vulgaris, folliculitis, and impetigo .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85929

	Topoisomerase II alpha Antibody (YA5621) alpha isozyme; ATP hydrolyzing DNA topoisomerase II alfa; DNA gyrase; DNA topoisomerase; ATP hydrolyzing; DNA topoisomerase 2 alpha; DNA topoisomerase 2-alpha; DNA topoisomerase II 170 kD; DNA topoisomerase II alpha isozyme; DNA topoisomerase II; DNA Topoisomerase2; TOP 2A; TOP2; TOP2A; TOP2A_HUMAN; Topoisomerase DNA II alpha 170 kDa; TP2A	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA5621) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Topoisomerase II alpha.