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Cat. No.: HY-101967

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GSK299423

Name: GSK299423
Brand: MedChemExpress
SKU: HY-101967
Price: 2445.00 USD
Availability: InStock
Rating: 5 (1 reviews)

GSK 299423 is an antibiotic agent.GSK299423 shows potent inhibition of supercoiling by DNA gyrase from S. aureus(IC₅₀=14 nM）and Escherichia coli(IC₅₀=100 nM.

For research use only. We do not sell to patients.

CAS No.: 1352149-24-6
Formula: C₂₅H₂₇N₅O₂S
Molecular Weight:461.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

GSK299423 Chemical Structure

CAS No.: 1352149-24-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

GSK 299423 is an antibiotic agent.GSK299423 shows potent inhibition of supercoiling by DNA gyrase from S. aureus(IC₅₀=14 nM）and Escherichia coli(IC₅₀=100 nM^[1].

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	2 μM Compound: 35, GSK299423	Inhibition of human ERG expressed in HEK293 cells by patch-clamp electrophysiology Inhibition of human ERG expressed in HEK293 cells by patch-clamp electrophysiology	[PMID: 22047689]

Chemical Information

CAS No. 1352149-24-6
Molecular Weight 461.58
Formula C₂₅H₂₇N₅O₂S
SMILES

N#CC1=CN=C2C=CC(OC)=CC2=C1CCN3CCC(CC3)NCC4=NC=C5OCSC5=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bax BD, et al. Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature. 2010;466(7309):935-940. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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