1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Clinafloxacin hydrochloride

Clinafloxacin hydrochloride (Synonyms: AM 1091 hydrochloride; CI 960 hydrochloride; PD127391 hydrochloride)

Cat. No.: HY-B0536A
Handling Instructions

Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro. Clinafloxacin hydrochloride is against DNA gyrase and topoisomerase IV of S. aureus with IC50 values of 0.92 µg/ml and 1.62 µg/ml, respectively.

For research use only. We do not sell to patients.

Clinafloxacin hydrochloride Chemical Structure

Clinafloxacin hydrochloride Chemical Structure

CAS No. : 105956-99-8

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Description

Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro[1]. Clinafloxacin hydrochloride is against DNA gyrase and topoisomerase IV of S. aureus with IC50 values of 0.92 µg/ml and 1.62 µg/ml, respectively[2].

IC50 & Target

MIC: 1 μg/ml (parC-gyrA mutants,S. pneumonia)[1]

In Vitro

Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants[2].
Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of S. aureus. It against Wild type S. aureus, gyrA mutant S. aureus and gyrA mutant S. aureus with MIC values of 0.016 µg/ml, 0.063 µg/ml and 0.915 µg/ml, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.
With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.25

Formula

C₁₇H₁₈Cl₂FN₃O₃

CAS No.

105956-99-8

SMILES

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CC(N)CC4)=C3Cl)C1=O)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ClinafloxacinAM 1091CI 960PD127391AM1091AM-1091CI960CI-960PD 127391PD-127391BacterialAntibioticanaerobic pathogenantibioticbacteriaS. aureuspneumococcal meningitisInhibitorinhibitorinhibit

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Clinafloxacin hydrochloride
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