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Cat. No.: HY-132923

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NBTIs-IN-4

NBTIs-IN-4 demonstrates potent antibacterial activity against diverse Gram-positive pathogens, inhibition of both DNA gyrase and topoisomerase IV, a low frequency of resistance.

For research use only. We do not sell to patients.

CAS No.: 2758890-16-1
Formula: C₂₂H₂₄FN₅O₅S
Molecular Weight:489.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NBTIs-IN-4 Chemical Structure

CAS No.: 2758890-16-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NBTIs-IN-4 demonstrates potent antibacterial activity against diverse Gram-positive pathogens, inhibition of both DNA gyrase and topoisomerase IV, a low frequency of resistance.

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	>125 μM Compound: 79	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 34614347]
HepG2	IC₅₀	>125 μM Compound: 79	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 34614347]
THP-1	IC₅₀	>125 μM Compound: 79	Cytotoxicity against human THP-1 cells Cytotoxicity against human THP-1 cells	[PMID: 34614347]

Chemical Information

CAS No. 2758890-16-1
Molecular Weight 489.52
Formula C₂₂H₂₄FN₅O₅S
SMILES

COC1=CC=C(C2=N1)N=CC(F)=C2C[C@@H]([C@@H]3OC[C@H](CO3)NCC4=NN=C5OCCSC5=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu Y, et al. Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA. J Med Chem. 2021 Oct 28;64(20):15214-15249. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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