DNA Gyrase-IN-6
Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 3034242-80-0
- Formula: C18H16Cl2N4O4S
- Molecular Weight:455.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DNA gyrase, Topoisomerase IV[1]
Antibacterial agent 138 (compound 7a) inhibits DNA gyrase and topoisomerase IV from S. aureus (IC50=1.22 nM and 8.0 nM, repsectivley), E. coli (IC50=<10 nM and 44 nM, repsectivley), A. baumannii (IC50=2.42 nM and 119.7 nM, repsectivley), and P. aeruginosa (IC50=<10 nM and 27.5 nM, repsectivley) with low nanomolar ranges[1].
Antibacterial agent 138 (up to 100 μM) shows no cytotoxicity on a breast cancer MCF-7 cell line and a liver cancer HepG2 cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3034242-80-0
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Molecular Weight 455.32
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Formula C18H16Cl2N4O4S
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SMILES
CC1=C(C(Cl)=C(N1)C(NC2=NC3=C(S2)C=C(C=C3N4CCOCC4)C(O)=O)=O)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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