Antibacterial agent 327
Antibacterial agent 327 (Compound 6f) is an Antibacterial agent. Antibacterial agent 327 potently inhibits the supercoiling activity of Staphylococcus aureus DNA gyrase with an IC50 of 0.28 μM. It also inhibits the ATPase activities of DNA gyrase and Topoisomerase IV, as well as the decatenation activity of Topoisomerase IV (IC50: 0.43 μM, 0.73 μM, and 2.31 μM, respectively). Antibacterial agent 327 potently inhibits Clostridioides difficile and methicillin-resistant Staphylococcus aureus (HY-121544), with an MIC of 0.78 μg/mL for both. Antibacterial agent 327 inhibits Escherichia coli with an MIC50 of 0.78 μg/mL.
For research use only. We do not sell to patients.
- CAS No.: 1311163-39-9
- Formula: C34H42ClN3O17S
- Molecular Weight:832.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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TOPO IV 2.31 (Deca μM (IC50) |
TOPO IV 0.73 (ATPa μM (IC50) |
Antibacterial agent 327 potently inhibits Clostridium difficile and Methicillin (HY-121544)-resistant Staphylococcus aureus, with an MIC of 0.78 μg/mL for both[1].
Antibacterial agent 327 (0.78-100 μg/mL) potently inhibits Escherichia coli, with an MIC50 of 0.78 μg/mL; meanwhile, it shows weak activity against Pseudomonas aeruginosa and Salmonella typhimurium, and limited activity against Klebsiella pneumoniae[1].
Antibacterial agent 327 (0.28-2.31 μM) potently inhibits the supercoiling activity of Staphylococcus aureus DNA gyrase with an IC50 of 0.28 μM. It also inhibits the ATPase activities of DNA gyrase and topoisomerase IV, as well as the decatenation activity of topoisomerase IV[1].
Antibacterial agent 327 exhibits an IC50 value of 85.52 μM against WI-38 fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1311163-39-9
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Molecular Weight 832.23
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Formula C34H42ClN3O17S
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SMILES
CC(O[C@H]([C@H]([C@@H](O[C@@H]1COC(C)=O)NC(N/N=C/C2=CC=C(C=C2)Cl)=S)OC(C)=O)[C@@H]1O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(C)=O)OC(C)=O)OC(C)=O)OC(C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 327 Related Classifications
HY-181819 Related Classifications
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- Antibacterial agent 327
- 1311163-39-9
- Antibacterial agent327
- Antibacterial agent-327
- Bacterial
- Topoisomerase
- Staphylococcus aureus DNA gyrase
- methicillin-resistant Staphylococcus aureus
- Staphylococcus aureus
- DNA gyrase
- Clostridium difficile
- topoisomerase IV
- WI-38 human fibroblast cells
- Gram-negative bacterial strains
- Escherichia coli
- Gram-positive bacterial strains
- Inhibitor
- inhibitor
- inhibit