Nalidixic acid sodium salt
Based on 2 publication(s) in Google Scholar
Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 3374-05-8
- Formula: C12H11N2NaO3
- Molecular Weight:254.22
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Nalidixic acid sodium salt
MoreAll Antibiotic Isoforms
MoreAll Topoisomerase Isoforms
More
Biological Activity
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Quinolone |
Topoisomerase |
Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3374-05-8
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Appearance Solid
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Molecular Weight 254.22
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Formula C12H11N2NaO3
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Color White to off-white
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SMILES
O=C(C1=CN(CC)C2=NC(C)=CC=C2C1=O)O[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
J Biol Chem
Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. [Abstract]2022 Feb;298(2):101554. PMID: 34973337
Solvent & Solubility
H2O : 116.67 mg/mL (458.93 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.9336 mL | 19.6680 mL | 39.3360 mL | 98.3400 mL |
| 5 mM | 0.7867 mL | 3.9336 mL | 7.8672 mL | 19.6680 mL | |
| 10 mM | 0.3934 mL | 1.9668 mL | 3.9336 mL | 9.8340 mL | |
| 15 mM | 0.2622 mL | 1.3112 mL | 2.6224 mL | 6.5560 mL | |
| 20 mM | 0.1967 mL | 0.9834 mL | 1.9668 mL | 4.9170 mL | |
| 25 mM | 0.1573 mL | 0.7867 mL | 1.5734 mL | 3.9336 mL | |
| 30 mM | 0.1311 mL | 0.6556 mL | 1.3112 mL | 3.2780 mL | |
| 40 mM | 0.0983 mL | 0.4917 mL | 0.9834 mL | 2.4585 mL | |
| 50 mM | 0.0787 mL | 0.3934 mL | 0.7867 mL | 1.9668 mL | |
| 60 mM | 0.0656 mL | 0.3278 mL | 0.6556 mL | 1.6390 mL | |
| 80 mM | 0.0492 mL | 0.2459 mL | 0.4917 mL | 1.2293 mL | |
| 100 mM | 0.0393 mL | 0.1967 mL | 0.3934 mL | 0.9834 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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