1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
    Antibiotic
    Topoisomerase
  3. Nalidixic acid sodium salt

Nalidixic acid sodium salt 

Cat. No.: HY-B0398A
Handling Instructions

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.

For research use only. We do not sell to patients.

Nalidixic acid sodium salt Chemical Structure

Nalidixic acid sodium salt Chemical Structure

CAS No. : 3374-05-8

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Description

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2].

IC50 & Target[1]

Topoisomerase

 

In Vitro

Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1].

In Vivo

The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli, A. aerobacter, Proteus mirabilis, Shigella fkxneri, the ED50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively[1].
The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg[1].

Molecular Weight

254.22

Formula

C₁₂H₁₁N₂NaO₃

CAS No.

3374-05-8

SMILES

O=C(C1=CN(CC)C2=NC(C)=CC=C2C1=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Nalidixic acidBacterialAntibioticTopoisomeraseantibioticDNA gyrasesusceptible bacteriaEscherichia coliKlebsiella pneuiiioniaeAerobacter aeroyenesProteus sppSalmonella spp.Inhibitorinhibitorinhibit

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Nalidixic acid sodium salt
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HY-B0398A
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