1. Anti-infection Cell Cycle/DNA Damage
  2. Bacterial Antibiotic Topoisomerase
  3. Nalidixic acid sodium salt

Nalidixic acid sodium salt 

Cat. No.: HY-B0398A Purity: 99.74%
COA Handling Instructions

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.

For research use only. We do not sell to patients.

Nalidixic acid sodium salt Chemical Structure

Nalidixic acid sodium salt Chemical Structure

CAS No. : 3374-05-8

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100 mg USD 75 In-stock
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Nalidixic acid sodium salt

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2].

IC50 & Target[1]

Quinolone

 

Topoisomerase

 

In Vitro

Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli, A. aerobacter, Proteus mirabilis, Shigella fkxneri, the ED50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively[1].
The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

254.22

Formula

C12H11N2NaO3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(CC)C2=NC(C)=CC=C2C1=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (491.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9336 mL 19.6680 mL 39.3360 mL
5 mM 0.7867 mL 3.9336 mL 7.8672 mL
10 mM 0.3934 mL 1.9668 mL 3.9336 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Nalidixic acid sodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Nalidixic acid sodium salt
Cat. No.:
HY-B0398A
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