1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Pazufloxacin

Pazufloxacin (Synonyms: T3761)

Cat. No.: HY-B0724B
Handling Instructions

Pazufloxacin (T-3761) is a fluoroquinolone antibiotic.

For research use only. We do not sell to patients.

Pazufloxacin Chemical Structure

Pazufloxacin Chemical Structure

CAS No. : 127045-41-4

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Description

Pazufloxacin (T-3761) is a fluoroquinolone antibiotic. Target: Antibacterial Pazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmonary, and urinary tract infections with gram-positive and gram-negative bacteria, including quinolone-resistant Serratia marcescens and Pseudomonas aeruginosa. The in vivo activity of T-3761 was comparable to or greater than those of ofloxacin, ciprofloxacin, norfloxacin, and tosufloxacin against most infection models in mice. The activities of T-3761 were lower than those of tosufloxacin against gram-positive bacterial systemic and pulmonary infections in mice but not against infections with methicillin-resistant Staphylococcus aureus [1]. T-3761 had a broad spectrum of activity and had potent activity against gram-positive and -negative bacteria. The MICs of T-3761 against 90% of the methicillin-susceptible Staphylococcus aureus, methicillin-susceptible and -resistant Staphylococcus epidermidis, and Clostridium spp. tested were 0.39 to 6.25 micrograms/ml. The MBCs of T-3761 were either equal to or twofold greater than the MICs. The 50% inhibitory concentrations of T-3761 for DNA gyrases isolated from E. coli and P. aeruginosa were 0.88 and 1.9 micrograms/ml, respectively [2].

Clinical Trial
Molecular Weight

318.30

Formula

C16H15FN2O4

CAS No.
SMILES

O=C(C(C1=O)=CN2[[email protected]@H](C)COC3=C(C4(N)CC4)C(F)=CC1=C23)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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