Albicidin 

Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight^[1][2].

Albicidin (30-200 nM) inhibits the DNA gyrase supercoiling activity of E. coli, with an IC₅₀ of approximately 40 nM^[1].
Albicidin exhibits potent antibacterial activity against Escherichia coli (including fluoroquinolone-resistant strains), Salmonella enteritidis, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus, with MIC values ranging from 0.031 to 16 μg/mL^[1].
Albicidin (0-3200 nM; 30-60 min) inhibits DNA supercoiling mediated by wild-type E. coli DNA gyrase, with an IC₅₀ of 40 nM^[2].
Albicidin (0-1600 nM; 30-60 min) inhibits the DNA supercoiling activity of mitochondrial and chloroplast DNA gyrases in Arabidopsis thaliana, with an IC₅₀ of 50 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

842.81

C₄₄H₃₈N₆O₁₂

1622253-00-2

O=C(C1=C(C(OC)=C(C=C1)NC(C2=CC=C(C=C2)NC([C@H](CC#N)NC(C3=CC=C(C=C3)NC(/C(C)=C/C4=CC=C(C=C4)O)=O)=O)=O)=O)O)NC5=C(C(O)=C(C=C5)C(O)=O)OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kretz J, et al. Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors. Angew Chem Int Ed Engl. 2015;54(6):1969-1973.  [Content Brief]

  [2]. Hashimi SM, et al. The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob Agents Chemother. 2007;51(1):181-187.