Albicidin
Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight.
For research use only. We do not sell to patients.
- CAS No.: 1622253-00-2
- Formula: C44H38N6O12
- Molecular Weight:842.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DNA Gyrase |
Albicidin (30-200 nM) inhibits the DNA gyrase supercoiling activity of E. coli, with an IC50 of approximately 40 nM[1].
Albicidin exhibits potent antibacterial activity against Escherichia coli (including fluoroquinolone-resistant strains), Salmonella enteritidis, Pseudomonas aeruginosa, Staphylococcus aureus, and Micrococcus luteus, with MIC values ranging from 0.031 to 16 μg/mL[1].
Albicidin (0-3200 nM; 30-60 min) inhibits DNA supercoiling mediated by wild-type E. coli DNA gyrase, with an IC50 of 40 nM[2].
Albicidin (0-1600 nM; 30-60 min) inhibits the DNA supercoiling activity of mitochondrial and chloroplast DNA gyrases in Arabidopsis thaliana, with an IC50 of 50 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1622253-00-2
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Molecular Weight 842.81
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Formula C44H38N6O12
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SMILES
O=C(C1=C(C(OC)=C(C=C1)NC(C2=CC=C(C=C2)NC([C@H](CC#N)NC(C3=CC=C(C=C3)NC(/C(C)=C/C4=CC=C(C=C4)O)=O)=O)=O)=O)O)NC5=C(C(O)=C(C=C5)C(O)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kretz J, et al. Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors. Angew Chem Int Ed Engl. 2015;54(6):1969-1973. [Content Brief]
[2]. Hashimi SM, et al. The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob Agents Chemother. 2007;51(1):181-187. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Albicidin Related Classifications
HY-108988 Related Classifications
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