DNA gyrase/Topo IV-IN-3
DNA gyrase/Topo IV-IN-3 is an inhibitor of Escherichia coli DNA gyrase and Topoisomerase IV, with IC50 values of 1.75 μM and 3.47 μM, respectively. DNA gyrase/Topo IV-IN-3 acts as a biofilm inhibitor and exhibits antibacterial activity against both Gram-negative and Gram-positive bacteria. DNA gyrase/Topo IV-IN-3 can be used in studies related to bacterial infections.
For research use only. We do not sell to patients.
- Formula: C37H30ClFN6O5
- Molecular Weight:693.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
TOPO IV 3.47 μM (IC50) |
In Vitro
DNA gyrase/Topo IV-IN-3 (Compound 6g) exhibits strong antibacterial activity against E. coli, moderate activity against P. aeruginosa and S. aureus, and negligible activity against B. subtilis in the disk diffusion assay[1].
DNA gyrase/Topo IV-IN-3 exhibits inhibitory activity against the growth of E. coli comparable to that of Ciprofloxacin (HY-B0356), while its inhibitory activity against P. aeruginosa and S. aureus is half that of Ciprofloxacin, with MIC values of 0.025, 0.025 and 0.125 μg/mL, respectively[1].
DNA gyrase/Topo IV-IN-3 (50 μM; 4 days) exhibits no cytotoxicity against the normal human mammary epithelial cell line MCF-10A[1].
DNA gyrase/Topo IV-IN-3 (0.00625-0.025 μg/mL) exhibits significant dose-dependent antibiofilm activity against E. coli, with an inhibition rate of 96% at its MIC of 0.025 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-10A cells
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Concentration:50 μM
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Incubation Time:4 days
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Result:Maintained greater than 92% cell viability in MCF-10 A cells, indicating no cytotoxicity at the tested concentration.
Chemical Information
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Molecular Weight 693.12
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Formula C37H30ClFN6O5
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SMILES
OC(C1=CN(C2CC2)C3=CC(N4CCN(CC(NC5=CC=C(C(N6)=CC(C7=CC=CC(Cl)=C7)=C(C#N)C6=O)C=C5)=O)CC4)=C(F)C=C3C1=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DNA gyrase/Topo IV-IN-3 Related Classifications
HY-183700 Related Classifications
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