2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt Anti-infection
  3. JAK Bacterial Orthopoxvirus
  4. Coumermycin A1

Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.

For research use only. We do not sell to patients.

CAS No. : 4434-05-3

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Based on 27 publication(s) in Google Scholar

Coumermycin A1 Related Antibodies

Top Publications Citing Use of Products
Bio/Physico-chemical Assay
WB
Histological Imaging/Staining
Cell Proliferation/Viability Assay

    Coumermycin A1 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 May 29:101592.  [Abstract]

    MYD88-GyrB or MYD88 mutant-GyrB MV4-11 cells stimulated with different reagents (Coumermycin A, 1 ng/mL; SSO, 50 μM) for 3 days were further used for T cell proliferation assay.

    Coumermycin A1 purchased from MedChemExpress. Usage Cited in: Inflammation. 2024 Feb;47(1):209-226.  [Abstract]

    The wet/dry ratio, cell counts and protein levels in BALF of lung tissue in LPS + FGF21 group were alleviated compared with LPS group, while the therapeutic effect of FGF21 was reversed by Coumermycin A1.

    Coumermycin A1 purchased from MedChemExpress. Usage Cited in: Inflammation. 2024 Feb;47(1):209-226.  [Abstract]

    Representative H&E staining image of the lung tissue of control group, LPS group, LPS + FGF21 group, and LPS + FGF21 +  Coumermycin A1 group (n = 10), scale bar = 50 μm.

    Coumermycin A1 purchased from MedChemExpress. Usage Cited in: Inflammation. 2024 Feb;47(1):209-226.  [Abstract]

    The lung injury score of control group, LPS group, LPS + FGF21 group, and LPS + FGF21 + Coumermycin A1 group was evaluated.

    Coumermycin A1 purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2023 Sep 5:954:175876.  [Abstract]

    MLE-12 cells were inoculated in 6-well plates and grown to 60% confluence. The cells were incubated with Coumermycin A1, JAK-IN-21, Colivelin TFA, and Stattic in culture medium for 48 h. The medium was then refreshed, followed by a 24-h pretreatment with EGCG, and finally exposure to LPS for 10 h. Protein levels of JAK2, p-JAK2, STAT3, and p-STAT3 were measured by western blotting.

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    Description

    Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.

    Cellular Effect
    Cell Line Type Value Description References
    MCF7 IC50
    2 μM
    Compound: Coumermycin A1
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		[PMID: 30048133]
    SK-BR-3 IC50
    2 μM
    Compound: Coumermycin A1
    Antiproliferative activity against human SKBR3 cells
    Antiproliferative activity against human SKBR3 cells
    		[PMID: 30048133]
    In Vitro

    Coumermycin A1-induced-JAK2 signal activation increases the mRNA level of SCOS2, but reducea leptin receptor mRNA level[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Coumermycin A1 Related Antibodies
    Molecular Weight

    1110.08

    Formula

    C55H59N5O20
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC(C1=CC=C(O[C@@H]([C@H](O)[C@H](OC(C2=CC=C(C)N2)=O)[C@H]3OC)OC3(C)C)C(C)=C1O4)=C(NC(C5=CNC(C(NC6=C(O)C7=CC=C(O[C@@H]([C@H](O)[C@H](OC(C8=CC=C(C)N8)=O)[C@H]9OC)OC9(C)C)C(C)=C7OC6=O)=O)=C5C)=O)C4=O
    Structure Classification
    Initial Source

    Streptomyces rishiriensis.
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 10 mg/mL (9.01 mM; ultrasonic and warming and adjust pH to 2 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9008 mL 4.5042 mL 9.0084 mL
    5 mM 0.1802 mL 0.9008 mL 1.8017 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.86%

    SDS (392 KB)

    COA (248 KB) HNMR (356 KB) LCMS (86 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.9008 mL 4.5042 mL 9.0084 mL 22.5209 mL
    5 mM 0.1802 mL 0.9008 mL 1.8017 mL 4.5042 mL
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    Coumermycin A1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Coumermycin A14434-05-3Coumermycin A 1Coumermycin A-1JAKBacterialOrthopoxvirusJanus kinaseInhibitorinhibitorinhibit

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