Search Result

Results for "

Glucosidase Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Amylases (26) Antibiotic (4) Apoptosis (9) Aryl Hydrocarbon Receptor (2) Bacterial (9) Bcl-2 Family (1) Carbonic Anhydrase (1) Cholinesterase (ChE) (4) COX (2) Dengue virus (3) Dipeptidyl Peptidase (4) DNA/RNA Synthesis (2) Endogenous Metabolite (12) Enterovirus (1) Flavivirus (3) Fungal (3) Glucokinase (2) Glutaminase (1) Glutathione Peroxidase (2) Glycosidase (203) HBV (2) HCV (2) HDAC (1) HIV (3) HIV Protease (1) HMG-CoA Reductase (HMGCR) (2) Interleukin Related (2) Isotope-Labeled Compounds (1) Lipoxygenase (3) NOD-like Receptor (NLR) (1) Opioid Receptor (2) P-glycoprotein (1) Parasite (3) Phosphatase (7) Phospholipase (1) PI3K (3) PPAR (3) Reactive Oxygen Species (2) TNF Receptor (2) Tyrosinase (4) α-synuclein (2)
By Research Areas:	Cancer (26) Cardiovascular Disease (7) Endocrinology (6) Infection (34) Inflammation/Immunology (20) Metabolic Disease (167) Neurological Disease (10)
Click Chemistry:	Azide (1)

224

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107532

N-Nonyldeoxynojirimycin NN-DNJ; Nonyl-DNJ	Glycosidase	Metabolic Disease
N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of *alpha-glucosidase* and *alpha-1,6-glucosidase* (IC₅₀s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown .

HY-159491

DPP-4-IN-11	Dipeptidyl Peptidase Glycosidase Amylases	Metabolic Disease
DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC₅₀=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of *α-glucosidase* (IC₅₀=3.02 μM) and α-amylase (IC₅₀=3.3 μM) .

HY-150723

PBI-6DNJ	Glycosidase	Metabolic Disease
PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against *α-glucosidase* from mice, with a K_i of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research .

HY-148575

α-Glucosidase-IN-23	Glycosidase	Metabolic Disease
α-Glucosidase-IN-23 is an orally active *α-Glucosidase* inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC₅₀ value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes .

HY-161522

α-Glucosidase-IN-63	Glycosidase Carbonic Anhydrase	Endocrinology
α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of *α-Glucosidase* (IC₅₀=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of K_i= 7.0 nM. α-Glucosidase-IN-63 is orally effective. .

HY-162286

α-Glucosidase-IN-50	Glycosidase	Metabolic Disease
α-Glucosidase-IN-50 (compound 8) is an inhibitor of *α-Glucosidase* .

HY-162287

α-Glucosidase-IN-51	Glycosidase	Metabolic Disease
α-Glucosidase-IN-51 (compound 9) is an inhibitor of *α-Glucosidase* .

HY-150560

α-Glucosidase-IN-11	Glycosidase	Metabolic Disease
α-Glucosidase-IN-11 is a highly permeable competitive *α-glucosidase* inhibitor with the IC₅₀ value of 0.56 μM. α-Glucosidase-IN-11 binds to Trp residues in α-glucosidase and regulates protein folding. α-Glucosidase-IN-11 can be used to regulate blood glucose levels .

HY-115978

α-Glucosidase-IN-2	Glycosidase	Metabolic Disease
α-Glucosidase-IN-2 (compound 5d) is a potent *α-Glucosidase* inhibitor with an IC₅₀ of 9.48 µM. α-Glucosidase-IN-2 is an antidiabetic agent .

HY-N11512

α-Glucosidase-IN-24	Glycosidase	Metabolic Disease
α-Glucosidase-IN-24 (Compound 13) is an *α-Glucosidase* inhibitor with an IC₅₀ of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis .

HY-155372

α-Glucosidase-IN-39	Glycosidase	Metabolic Disease
α-Glucosidase-IN-39 is a potent inhibitor of *α-glucosidase* enzyme with an IC₅₀** of 869.06 ppm. α-Glucosidase-IN-39 can used in study antidiabetic .

HY-155344

α-Glucosidase-IN-38	Glycosidase	Metabolic Disease
α-Glucosidase-IN-38 (Compound 11j) is a potent inhibitor of α-glucosidase inhibitor with IC₅₀ *of 12.44±0.38 μM.α-Glucosidase-IN-38 plays an important role in Diabetes mellitus (DM) .*

HY-149579

α-Glucosidase-IN-36	Glycosidase	Metabolic Disease
α-Glucosidase-IN-36 (compound 5g) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 6.69 ± 0.18 μM, K_i and K_is of 1.65 μM and 4.54 μM, respectively. α-Glucosidase-IN-36 may inhibit α-glucosidase activity by binding with its active site as well as changing the secondary structure of α-glucosidase. α-Glucosidase-IN-36 can be used for type 2 diabetes mellitus (T2DM) research .

HY-147823

α-Glucosidase-IN-6	Glycosidase	Metabolic Disease
α-Glucosidase-IN-6 (compound 18) is a competitive *α-glucosidase* inhibitor with an IC₅₀ of 5.69 µM. α-Glucosidase-IN-6 has anti-diabetic potential .

HY-157488

α-Glucosidase-IN-46	Glycosidase	Metabolic Disease
α-Glucosidase-IN-46 is a potent *α-glucosidase* inhibitor with an IC₅₀ of 26.0 μM. α-Glucosidase-IN-46 can be used for the research of type 2 diabetes .

HY-161318

α-Glucosidase-IN-52	Glycosidase	Metabolic Disease
α-Glucosidase-IN-52 (Compound 3h) is an *α-glucosidase* inhibitor with an IC₅₀ of 2.8 μM. α-Glucosidase-IN-52 can be used for diabetes research .

HY-157489

α-Glucosidase-IN-47	Glycosidase	Metabolic Disease
α-Glucosidase-IN-47 (compound 8H) is a non-competitive α-glucosidase (α-glucosidase) inhibitor with IC₅₀ value is 38.2 μM and K_i value is 38.2 μM. α-Glucosidase-IN-47 can be used in diabetes research. .

HY-156078

α-Glucosidase-IN-32	Glycosidase	Metabolic Disease
α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally active α-glucosidase inhibitor with an IC₅₀ value of 3.07 μM. α-Glucosidase-IN-32 complex with α-glucosidase through hydrogen bonds and hydrophobic interactions, led to changes in the conformation and secondary strictures of α-glucosidase and further the inhibition of the enzymatic activity. α-Glucosidase-IN-32 can be used for diabetic disease research .

HY-147718

α-Glucosidase-IN-5	Glutaminase	Metabolic Disease
α-Glucosidase-IN-5 (compound 8) is a potent *α-glucosidase* inhibitor with an IC₅₀ of 57.9 µM. α-Glucosidase-IN-5 has the potential for the research of diabetes mellitus .

HY-151142

α-Glucosidase-IN-18	Glycosidase	Metabolic Disease
α-Glucosidase-IN-18 (7B) is an orally active *α-glucosidase* inhibitor with an IC₅₀ value of 3.96 μM. α-Glucosidase-IN-18 has antidiabetic activity .

HY-146156

α-Glucosidase-IN-7	Glycosidase	Metabolic Disease
α-Glucosidase-IN-7 is a noncompetitive *α-glucosidase* inhibitor with an IC₅₀ value of 18.9 µM .

HY-150960

α-Glucosidase-IN-13	Glycosidase	Metabolic Disease
α-Glucosidase-IN-13 (Compound 8) is a *α-glucosidase* inhibitor with an IC₅₀ of 5.69 μM .

HY-163066

α-Glucosidase-IN-44	Glycosidase	Metabolic Disease
α-Glucosidase-IN-44 (compound IT4) is an inhibitor of *α-glucosidase* with IC₅₀ value of 2.35 μM. α-Glucosidase-IN-44 has an oral activity. α-Glucosidase-IN-44 suppresses fasting blood glucose levels in diabetic mice .

HY-161999

α-Glucosidase-IN-73	Glycosidase	Metabolic Disease Inflammation/Immunology
α-Glucosidase-IN-73 (compound 16b) is an *α-Glucosidase* inhibitor with IC₅₀ of 0.158 μM. α-Glucosidase-IN-73 can activate PPAR γ. α-Glucosidase-IN-73 can be used in anti-diabetic and anti-inflammatory studies .

HY-169406

α-Glucosidase-IN-76	Glycosidase	Cancer
α-Glucosidase-IN-76 (Compound 4r) is an inhibitor for *α-glucosidase* with an IC₅₀ of 5.44 μM. α-Glucosidase-IN-76 scavenges ABTS+ free radicals with a TEAC value of 0.49. α-Glucosidase-IN-76 inhibits the proliferation of T24 bladder cancer cell with IC₅₀ of 1.74 μM .

HY-147964

α-Glucosidase-IN-9	Glycosidase	Metabolic Disease
α-Glucosidase-IN-9 (compound 7) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 55.6 μM. α-Glucosidase-IN-9 can be used for type II diabetes research .

HY-147965

α-Glucosidase-IN-10	Glycosidase	Metabolic Disease
α-Glucosidase-IN-10 (compound 13) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 92.7 μM. α-Glucosidase-IN-10 can be used for type II diabetes research .

HY-151141

α-Glucosidase-IN-17	Glycosidase	Metabolic Disease
α-Glucosidase-IN-17 (Compound 12B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.79 μM. α-Glucosidase-IN-17 shows antidiabetic activity .

HY-151135

α-Glucosidase-IN-15	Glycosidase	Metabolic Disease
α-Glucosidase-IN-15 (Compound 14B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.34 μM. α-Glucosidase-IN-15 shows antidiabetic activity .

HY-W783267

α-Glucosidase-IN-35	Glycosidase	Metabolic Disease
α-Glucosidase-IN-35 (compound 1) is a kind of chromene. α-Glucosidase-IN-35 can be isolated from the aqueous extract of the aerial parts of Brickellia cavanillesii. α-Glucosidase-IN-35 is a potent inhibitor of *α-glucosidase* with an IC₅₀ value of 0.169 mg/mL .

HY-150959

α-Glucosidase-IN-12	Glycosidase	Metabolic Disease
α-Glucosidase-IN-12 (compound 14) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 10.20 μM .

HY-150961

α-Glucosidase-IN-14	Glycosidase	Metabolic Disease
α-Glucosidase-IN-14 (compound 5) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 5.22 μM .

HY-162262

α-Glucosidase-IN-48	Glycosidase	Metabolic Disease
α-Glucosidase-IN-48 (compound 9) is a potent inhibitor of α-Glucosidase, with IC₅₀ of 1.30 μM .

HY-162395

α-Glucosidase-IN-58	Glycosidase	Metabolic Disease
α-Glucosidase-IN-58 (Compound 6d) is an inhibitor for α-glucosidase with IC₅₀ of 1.47 μM .

HY-149341

α-Glucosidase-IN-28	Glycosidase	Metabolic Disease
α-Glucosidase-IN-28 (Compound 18) is a *α-Glucosidase* inhibitor (IC₅₀: 0.62 μM, K_i: 3.93 μM). α-Glucosidase-IN-28 binds to α-glucosidase at the original binding site (OBS), and forms multiple hydrophobic interactions with nearby amino acids. α-Glucosidase-IN-28 can be used for research of diabetes and related diseases .

HY-151145

α-Glucosidase-IN-21	Glycosidase	Metabolic Disease
α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity .

HY-151143

α-Glucosidase-IN-19	Glycosidase	Metabolic Disease
α-Glucosidase-IN-19 (Compound 6B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.63 μM. α-Glucosidase-IN-19 shows anti-diabetic activity .

HY-151144

α-Glucosidase-IN-20	Glycosidase	Metabolic Disease
α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity .

HY-157311

α-Glucosidase-IN-45	Glycosidase	Cancer
α-Glucosidase-IN-45 (compound 11E) is an inhibitor of *α-glucosidase. α-Glucosidase*-IN-45 is a novel indol-fused pyrano[2,3-D]pyrimidine compound .

HY-N12664

α-Glucosidase-IN-54	Glycosidase	Metabolic Disease
α-Glucosidase-IN-54 (compound 2) is a *α-glucosidase* inhibitor with the IC₅₀ of 0.011 mM, and can be isolated form Syzygium jambos (L.). α-Glucosidase-IN-54 can be used for study of diabetes .

HY-158697

α-Glucosidase-IN-65	Glycosidase	Metabolic Disease
α-Glucosidase-IN-65 (compound 5) is a Schiff base derivative of 3,4-dihydroxyphenylacetic acid. α-Glucosidase-IN-65 is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 12.84 μM .

HY-169251

α-Glucosidase-IN-75	Glycosidase	Cardiovascular Disease Metabolic Disease
α-Glucosidase-IN-75 (compound 13) is an *α-glucosidase* inhibitor with an IC₅₀ of 3.81 μM. α-Glucosidase-IN-75 can be used for the study of high glucose-induced cardiovascular diseases .

HY-149557

α-Amylase/α-Glucosidase-IN-5	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-5 (compound 4l) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 5.96 μM and 1.62 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-155241

α-Amylase/α-Glucosidase-IN-4	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-149668

α-Glucosidase-IN-41	Glycosidase	Metabolic Disease
α-Glucosidase-IN-41 (compound 5o) is a potent *α-glucosidase* inhibitor. α-Glucosidase-IN-41 can arise the changed secondary structure of α-Glu to hinder enzyme catalytic activity. α-Glucosidase-IN-41 can be used for diabetes mellitus research .

HY-161764

α-Glucosidase-IN-67	Amylases Glycosidase	Metabolic Disease
α-Glucosidase-IN-67 (compound 5k) is a potent *α-Glucosidase* inhibitor with IC₅₀ values of 0.31, 4.51 µM for alpha-glucosidase and alpha-amylase, respectively. α-Glucosidase-IN-67 has the potential for the research of type-2 diabetes .

HY-N12689

α-Glucosidase-IN-56	Glycosidase	Metabolic Disease
α-Glucosidase-IN-56 (compound 1) is an orally active, potent *α‐glucosidase* inhibitor with an IC₅₀ value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities .

HY-147879

α-Glucosidase-IN-8	Glycosidase	Metabolic Disease
α-Glucosidase-IN-8 (Compound 4k) is a competitive *α-glucosidase* inhibitor with an IC₅₀ of 0.18 µg/mL .

HY-156447

α-Glucosidase-IN-40	Glycosidase	Metabolic Disease
α-Glucosidase-IN-40 (compound 5) is a noncompetitive *α-glucosidase* enzyme** inhibitor with an IC₅₀ of 24.62 μM .

HY-162541

α-Glucosidase-IN-64	Glycosidase	Metabolic Disease
α-Glucosidase-IN-64 (compound 10) is a potent *α-glucosidase* inhibitor with an IC₅₀ value of 8.62 µM. α-Glucosidase-IN-64 is a polycyclic polyprenylated acylphloroglucinol that can be isolated from hypericum beanii .

Glucosidase Inhibitors

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products