(Z)-3-Butylidenephthalide
Based on 1 Customer Validation
(Z)-3-Butylidenephthalide is an antihyperglycemic agent by inhibiting the activity of intestinal and yeast R-glucosidases (IC50=2.35 mM; Ki=4.86 mM).
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 72917-31-8
- Formula: C12H12O2
- Molecular Weight:188.23
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
126.6 μM
Compound: 7
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Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
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[PMID: 16643021] |
| HEK293 | IC50 |
140.7 μM
Compound: 4j, Dehydroligustilide
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Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium influx preincubated for 5 mins followed by icilin challenge by Fluo-4-AM dye-based spectrofluorimetric analysis
Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of icilin-induced intracellular calcium influx preincubated for 5 mins followed by icilin challenge by Fluo-4-AM dye-based spectrofluorimetric analysis
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[PMID: 23993334] |
| HEK293 | IC50 |
153.3 μM
Compound: 4j, Dehydroligustilide
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Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of menthol-induced intracellular calcium influx preincubated for 5 mins followed by menthol challenge by Fluo-4-AM dye-based spectrofluorimetric analysis
Antagonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as inhibition of menthol-induced intracellular calcium influx preincubated for 5 mins followed by menthol challenge by Fluo-4-AM dye-based spectrofluorimetric analysis
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[PMID: 23993334] |
| HEK293 | IC50 |
44.5 μM
Compound: 4j, Dehydroligustilide
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Antagonist activity at rat recombinant TRPA1 overexpressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influx preincubated for 5 mins followed by allyl isothiocyanate challenge by Fluo-4-AM dye-based spectr
Antagonist activity at rat recombinant TRPA1 overexpressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influx preincubated for 5 mins followed by allyl isothiocyanate challenge by Fluo-4-AM dye-based spectr
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[PMID: 23993334] |
Chemical Information
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CAS No. 72917-31-8
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Appearance Liquid (Density: 1.204±0.06 g/cm3)
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Molecular Weight 188.23
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Formula C12H12O2
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Color Colorless to light yellow
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SMILES
O=C1O/C(C2=C1C=CC=C2)=C\CCC
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Synonyms
(Z)-Butylidenephthalide
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 56.2 mg/mL (298.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.3126 mL | 26.5632 mL | 53.1265 mL | 132.8162 mL |
| 5 mM | 1.0625 mL | 5.3126 mL | 10.6253 mL | 26.5632 mL | |
| 10 mM | 0.5313 mL | 2.6563 mL | 5.3126 mL | 13.2816 mL | |
| 15 mM | 0.3542 mL | 1.7709 mL | 3.5418 mL | 8.8544 mL | |
| 20 mM | 0.2656 mL | 1.3282 mL | 2.6563 mL | 6.6408 mL | |
| 25 mM | 0.2125 mL | 1.0625 mL | 2.1251 mL | 5.3126 mL | |
| 30 mM | 0.1771 mL | 0.8854 mL | 1.7709 mL | 4.4272 mL | |
| 40 mM | 0.1328 mL | 0.6641 mL | 1.3282 mL | 3.3204 mL | |
| 50 mM | 0.1063 mL | 0.5313 mL | 1.0625 mL | 2.6563 mL | |
| 60 mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 2.2136 mL | |
| 80 mM | 0.0664 mL | 0.3320 mL | 0.6641 mL | 1.6602 mL | |
| 100 mM | 0.0531 mL | 0.2656 mL | 0.5313 mL | 1.3282 mL |
(Z)-3-Butylidenephthalide Related Classifications
HY-N0336A Related Classifications
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