1. Anti-infection
    Apoptosis
    Metabolic Enzyme/Protease
  2. Parasite
    Bacterial
    Apoptosis
    Glucosidase
  3. Hexylresorcinol

Hexylresorcinol (Synonyms: 4-Hexylresorcinol)

Cat. No.: HY-B0986 Purity: ≥98.0%
Handling Instructions

Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage.

For research use only. We do not sell to patients.

Hexylresorcinol Chemical Structure

Hexylresorcinol Chemical Structure

CAS No. : 136-77-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
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10 g   Get quote  

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Description

Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage[1][2][3][4][5].

IC50 & Target

α-glucosidase[4]

In Vitro

Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive[1].
Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST)[2].
Hexylresorcinol (1-10 µg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation[3].
Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis[3].
Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: SCC-9 cells
Concentration: 1 µg/mL, 5 µg/mL, 10 µg/mL
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Inhibited SCC-9 cells proliferation.

Apoptosis Analysis[3]

Cell Line: SCC-9 cells
Concentration: 10 µg/mL
Incubation Time: 24 hours
Result: Induced morphological and biochemical changes in SCC-9 cells.
In Vivo

Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice (BALB/cAnNCrj-nu/nu), with SCC-9 cells xenograft[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection, daily, for 16 days
Result: Reduced tumor formation in vivo.
Molecular Weight

194.27

Formula

C₁₂H₁₈O₂

CAS No.

136-77-6

SMILES

OC1=CC=C(CCCCCC)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (514.75 mM; Need ultrasonic)

DMSO : ≥ 2.0 mg/mL (10.29 mM)

H2O : 1 mg/mL (5.15 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1475 mL 25.7374 mL 51.4748 mL
5 mM 1.0295 mL 5.1475 mL 10.2950 mL
10 mM 0.5147 mL 2.5737 mL 5.1475 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Hexylresorcinol4-HexylresorcinolParasiteBacterialApoptosisGlucosidaseantisepticanthelminticlocalanestheticanti-proliferativecancerchemopreventivenasopharyngealsquamouscellcarcinomatype-2diabetesangiogenesisInhibitorinhibitorinhibit

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