1. Anti-infection
    Metabolic Enzyme/Protease
  2. Influenza Virus
    Glucosidase
  3. IHVR-17028

IHVR-17028 

Cat. No.: HY-139663
Handling Instructions

IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research.

For research use only. We do not sell to patients.

IHVR-17028 Chemical Structure

IHVR-17028 Chemical Structure

CAS No. : 1428247-78-2

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Description

IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC50 of 0.24 μM. IHVR-17028 can be used for infectious diseases research[1][2].

In Vitro

In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC50 values of all >500 μM in MDBK, Huh7.5 or BHK cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a Cmax value of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T1/2 value is 0.88 hour after iv. adminstration[1].
IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection[1]
Dosage: 50 mg/kg
Administration: Treatment 1 day prior to virus challenging
Result: Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.
Animal Model: C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV[1]
Dosage: 25 mg/kg
Administration: Twice daily at 12 h interval; starting 4 h post infection for 10 days
Result: Inhibited EBOV infection in mice.
Molecular Weight

428.61

Formula

C₂₃H₄₄N₂O₅

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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IHVR-17028
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HY-139663
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