1. Metabolic Enzyme/Protease
  2. Glucosidase
  3. IHVR-19029

IHVR-19029 

Cat. No.: HY-124662 Purity: >98.0%
Handling Instructions

IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir (HY-14768) improves the antiviral efficacy.

For research use only. We do not sell to patients.

IHVR-19029 Chemical Structure

IHVR-19029 Chemical Structure

CAS No. : 1447464-73-4

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5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1900 Get quote
100 mg USD 2800 Get quote
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus (EBOV) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir (HY-14768) improves the antiviral efficacy[1][2][3][4].

In Vitro

IHVR-19029 efficiently inhibits Bovine viral diarrhea virus (BVDV), Tacaribe virus (TCRV) and Dengue virus (DENV) with EC50s of 0.25, 0.74, and 1.25 μM, respectively[2]. The combination of IHVR-19029 and Favipiravir (HY-14768) synergistically inhibits the replication of Yellow fever and Ebola viruses in cultured cells[4].

In Vivo

IHVR-19029 (25-75 mg/kg; I.p.; twice daily for 10 days) inhibits EBOV and MARV infection in mice[2].
IHVR-19029 (5 mg/kg; i.v.) has AUC, C0, T1/2, CL and Vd values of 1383 μg*h/mL, 1.79 μg/mL, 1.2 hours, 3.49 L/h/kg, and 3.0 L/kg, respectively[2].
IHVR-19029 (75/5/5 mg/kg; p.o./i.m./i.p.) has AUC values of 945/1839/983 μg*h/mL, Cmax values of 0.26/1.23/1.33 μg/ml, Tmax values of 2.1/0.1/0.17 hours, and F values of 4.6/71/133%, respectively[2].

Animal Model: BALB/c mice (12 week 233 of age) (MARV infection)[2]
Dosage: 25, 75 mg/kg
Administration: I.p.; twice daily, until 10 days
Result: Significant protection of Marburg virus (MARV) induced death were observed.
Animal Model: C57B1/6 mice (8–12 week of age) (EBOV infection)[2]
Dosage: 25, 75 mg/kg
Administration: I.p.; twice daily for 10 days
Result: Significant survival were observed.
Molecular Weight

443.62

Formula

C₂₃H₄₅N₃O₅

CAS No.

1447464-73-4

SMILES

O=C(NC(C)(C)C)N(C1CCCCC1)CCCCCCN2[[email protected]](CO)[[email protected]@H](O)[[email protected]](O)[[email protected]@H](O)C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (563.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2542 mL 11.2709 mL 22.5418 mL
5 mM 0.4508 mL 2.2542 mL 4.5084 mL
10 mM 0.2254 mL 1.1271 mL 2.2542 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (14.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (14.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (14.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IHVR-19029IHVR19029IHVR 19029GlucosidaseendoplasmicreticulumreplicationhemorrhagicfeverinfectionEBOVDENVRiftValleyvirusInhibitorinhibitorinhibit

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IHVR-19029
Cat. No.:
HY-124662
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