Notoginsenoside R2 (Synonyms: 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2)

Cat. No.: HY-N0909 Purity: 98.14%: FAQs
Data Sheet SDS COA Handling Instructions

Notoginsenoside R2 is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.

For research use only. We do not sell to patients.

Notoginsenoside R2 Chemical Structure

CAS No. : 80418-25-3

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1 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
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Description

Notoginsenoside R2 is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.

Molecular Weight

770.99

Appearance

Solid

Formula

C₄₁H₇₀O₁₃

CAS No.

80418-25-3

SMILES

C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(C[C@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@@](OC[C@@H](O)[C@@H]5O)([H])[C@@H]5O)[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC6)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (129.70 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2970 mL	6.4852 mL	12.9703 mL
5 mM	0.2594 mL	1.2970 mL	2.5941 mL
10 mM	0.1297 mL	0.6485 mL	1.2970 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (3.24 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 98.78%

Select Batch:

Data Sheet (282 KB) SDS (252 KB)

COA (263 KB) HNMR (165 KB) CNMR (155 KB) RP-HPLC (648 KB) MS (179 KB)

Handling Instructions (2659 KB)

References

[1]. Meng XB, et al. P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells. Evid Based Complement Alternat Med. 2013;2013:971712. [Content Brief]

[2]. González-Burgos E, et al. Potential neuroprotective activity of Ginseng in Parkinson's disease: a review. J Neuroimmune Pharmacol. 2015 Mar;10(1):14-29. [Content Brief]

Notoginsenoside R2 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Notoginsenoside R280418-25-320(S)-Notoginsenoside R2 Ginsenoside Ng-R2Notoginsenoside R 2Notoginsenoside R-2ApoptosisInhibitorinhibitorinhibit

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