Kuwanon G  (Synonyms: クワノンG)

Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis^{[1][2][3][4][5]}.

Kuwanon G (5-70 μM; 48 h) can inhibit the apoptosis of HT22 cells induced by Advanced glycation end products (HY-NP165) and the elevation of MDA and ROS levels, and restore the intracellular Ach level. The mechanism involves the PI3K/Akt/GSK3αβ signaling pathway^[1].
Kuwanon G (0-20 μg/mL; 0-10 min) has an MIC of 8.0 μg/mL for Streptococcus mutans^[2].
Kuwanon G (0-160 μM; 1-24 h) can inhibit the proliferation, migration and invasion, promote cell apoptosis, and inhibit the expression of MMP2 and MMP9 in gastric cancer cells. The mechanism involves the inhibition of the PI3K/AKT/mTOR pathway^[3].
Kuwanon G (2-20 μM; 24 h) can inhibit lipid accumulation and the mRNA levels of inflammatory factors in RAW 264.7 cells treated with ox-LDL (HY-NP135). The mechanism involves the activation of the LXRα-ABCA1/ABCG1 pathway and the inhibition of NF-κB^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kuwanon G (20-40 μM; 2 weeks) exhibits anti-tumor activity in the MGC 803 xenograft mouse model^[3].
Kuwanon G (5 mg/kg; intraperitoneal injection; once every other day; 16 weeks) has an ameliorative effect in the atherosclerotic mouse model of ApoE^-/- fed a high-fat diet^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

692.71

C₄₀H₃₆O₁₁

75629-19-5

Solid

Light yellow to yellow

O=C1C(C/C=C(C)\C)=C(C2=CC=C(O)C=C2O)OC3=C([C@H]4C=C(C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=CC(O)=C13

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Gan WJ, et al. Kuwanon G protects HT22 cells from advanced glycation end product-induced damage. Exp Ther Med. 2021 May;21(5):425.  [Content Brief]

  [2]. Park KM, et al. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol. 2003 Feb;84(2-3):181-5.  [Content Brief]

  [3]. Geng Z, et al. [Kuwanon G inhibits growth, migration and invasion of gastric cancer cells by regulating the PI3K/AKT/mTOR pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Aug 20;44(8):1476-1484.  [Content Brief]

  [4]. Liu XX, et al. Kuwanon G attenuates atherosclerosis by upregulation of LXRα-ABCA1/ABCG1 and inhibition of NFκB activity in macrophages. Toxicol Appl Pharmacol. 2018 Feb 15;341:56-63.  [Content Brief]

  [5]. Mihara S, et al. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9.  [Content Brief]