Search Result

Isoforms Recommended:	Plasmodium

Results for "

plasmodium

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (1) Antibiotic (6) Apoptosis (4) Bacterial (10) Biochemical Assay Reagents (1) Cathepsin (3) CDK (1) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) Dihydroorotate Dehydrogenase (6) DNA Methyltransferase (2) DNA/RNA Synthesis (3) Endogenous Metabolite (2) Eukaryotic Initiation Factor (eIF) (1) Farnesyl Transferase (2) Fungal (1) GLUT (2) GSK-3 (1) HCV (2) HDAC (3) HSP (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Lactate Dehydrogenase (1) Na+/K+ ATPase (1) NF-κB (1) Parasite (107) Phosphodiesterase (PDE) (1) PI3K (1) PI4K (6) Proteasome (1) SARS-CoV (1)
By Research Areas:	Cancer (11) Infection (117) Inflammation/Immunology (8) Neurological Disease (1)

By Targets:

Aminoacyl-tRNA Synthetase (1)

Antibiotic (6)

Apoptosis (4)

Bacterial (10)

Biochemical Assay Reagents (1)

Cathepsin (3)

CDK (1)

Cytochrome P450 (1)

Dihydrofolate reductase (DHFR) (1)

Dihydroorotate Dehydrogenase (6)

DNA Methyltransferase (2)

DNA/RNA Synthesis (3)

Endogenous Metabolite (2)

Eukaryotic Initiation Factor (eIF) (1)

Farnesyl Transferase (2)

Fungal (1)

GLUT (2)

GSK-3 (1)

HCV (2)

HDAC (3)

HSP (1)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (1)

Lactate Dehydrogenase (1)

Na+/K+ ATPase (1)

NF-κB (1)

Parasite (107)

Phosphodiesterase (PDE) (1)

PI3K (1)

PI4K (6)

Proteasome (1)

SARS-CoV (1)

By Research Areas:

Cancer (11)

Infection (117)

Inflammation/Immunology (8)

Neurological Disease (1)

122

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132170

DSM502	Dihydroorotate Dehydrogenase Parasite	Infection
DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502 exhibits nanomolar potency againsts Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs .

HY-132171A

DSM705 hydrochloride	Dihydroorotate Dehydrogenase Parasite	Infection
DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC₅₀=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs .

HY-132171

DSM705	Dihydroorotate Dehydrogenase Parasite	Infection
DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound .

HY-156105

8304-vs	Parasite Proteasome	Infection
8304-vs is a macrocyclic anti-Plasmodial agent that covalently and irreversibly targets the Plasmodium proteasome. 8304-vs effectively inhibits the growth of Plasmodium falciparum .

HY-149289

DNMT-IN-3	Parasite DNA Methyltransferase	Others
DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC₅₀ of 60 nM against Plasmodium falciparum (Plasmodium). DNMT-IN-3 can be used for malaria related research .

HY-162072

PfThrRS-IN-1	Parasite	Infection
PfThrRS-IN-1 (compound 11) is a potent inhibitor of Plasmodium falciparum threonyl tRNA synthetase (PfThrRS), with the IC₅₀ value of 0.1 μM. PfThrRS-IN-1 is a potent antimalaria agent .

HY-157840

Anti-infective agent 9	Parasite	Infection
Anti-infective agent 9 (compound 1) is a Plasmodium falciparum inhibitor (IC₅₀=600 nM), can downregulate pyruvate levels and TCA cycle in Plasmodium. Anti-infective agent 9It has good metabolic stability and low toxicity to human liver cells. The study found, Anti-infective agent 9Potential targets for inhibiting Plasmodium falciparum are not 1-deoxidation-d-xylulose-5-Phosphate synthase (DXPS) .

HY-N9320

13,21-Dihydroeurycomanone	Parasite	Infection
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii .

HY-12912

KDU691	PI4K Parasite	Infection
KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a Plasmodium PI4K inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites .

HY-N0352

Tuberostemonine

Parasite Infection

Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP ⁺ reductases (pfFNR) .

Tuberostemonine	Parasite	Infection
Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP ⁺ reductases (pfFNR) .

HY-N8383

Butyrolactone V	Parasite	Infection
Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC₅₀ of 7.9 µg/ml .

HY-135619

DHODH-IN-4	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection Inflammation/Immunology
DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC₅₀ values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity .

HY-19364

Ferroquine 2 Publications Verification Ferrochloroquine; SSR97193	Parasite	Infection
Ferroquine (Ferrochloroquine), a ferrocenyl analogue of Chloroquine, is an antimalarial agent. Ferroquine shows parasiticidal effect on *Plasmodium* by inducing oxidative stress and the subsequent destruction of the membrane .

HY-135648

PfDHODH-IN-1	Parasite Lactate Dehydrogenase DNA/RNA Synthesis	Infection
PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity .

HY-145912

RYL-552S	Parasite	Infection Inflammation/Immunology
RYL-552S kills drug-resistant strains of Plasmodium falciparum. RYL-552S can efficiently kill asexual blood-stage parasites in vitro .

HY-148035

Plm IV inhibitor-2	Parasite	Infection
Plm IV inhibitor-2 (compound 3) is a potent digestive vacuole plasmepsins IV (Plm IV) inhibitor with IC₅₀ values of 24 nM, 70 nM and 0.3 μM for Plm IV, II and I, respectively. Plm IV inhibitor-2 can be used to research malaria caused by Plasmodium parasites .

HY-155130

Antimalarial agent 31

Parasite Infection

Antimalarial agent 31 (compound 7k) is an orally active Plasmodium falciparum aspartic protease plasmepsin X (PMX) inhibitor .

Antimalarial agent 31	Parasite	Infection
Antimalarial agent 31 (compound 7k) is an orally active Plasmodium falciparum aspartic protease plasmepsin X (PMX) inhibitor .

HY-153007

DHFR-IN-5	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a K_i value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity .

HY-N8338

Pancixanthone A	Parasite	Infection
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Parasite	Infection
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-145327

Antimalarial agent 7	Na+/K+ ATPase Parasite	Infection
Antimalarial agent 7 is a potent inhibitor of PfATP4. PfATP4 is an essential ion pump on the parasite surface. Antimalarial agent 7 has the potential for the research of human malaria parasite, Plasmodium falciparum .

HY-162238

OSM-S-106	Parasite	Infection
OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. OSM-S-106 inhibits protein translation and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and low intrinsic clearance by human microsomes .

HY-106866

Bulaquine CDRI 80/53; Elubaquine	Parasite	Infection
Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria .

HY-161079

TDI-8304	Parasite	Infection
TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes .

HY-121211

Digitolutein	Parasite	Infection
Digitolutein is a natural product that can be isolated from the stem bark and the roots of Morinda lucida Benth. Digitolutein effectively inhibits the growth of Plasmodium falciparum with an IC₅₀ value of 12.92 μg/mL. Digitolutein can be used for the research of infection .

HY-148315

GLUT1-IN-2	GLUT	Infection
GLUT1-IN-2 (compound 17) is a GLUT1 inhibitor with an IC₅₀ value of 12 μM. GLUT1-IN-2 shows inhibitory effect to Plasmodium falciparum hexose transporter PfHT with an IC₅₀ value of 13 μM. GLUT1-IN-2 can be used for the research of infection .

HY-135666

DHODH-IN-8	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC₅₀s of 0.13 μM and 47.4 μM, and K_is of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity .

HY-W078844

PfDHODH-IN-2	Dihydroorotate Dehydrogenase Parasite	Infection
PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC₅₀ of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria .

HY-N5109

Cheilanthifoline	Parasite	Infection
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-120104

Nitidanin (±)-Nitidanin	Parasite HCV	Infection
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection .

HY-103397

Nanaomycin A	DNA Methyltransferase Parasite	Infection Cancer
Nanaomycin A is the first selective DNMT3B inhibitor with an IC₅₀ of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells . Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC₈₀ value of 33.1 nM .

HY-103353

SID 26681509 4 Publications Verification	Cathepsin Parasite	Infection Cancer
SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC₅₀ of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits *Leishmania major* with IC₅₀s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G .

HY-103353A

SID 26681509 quarterhydrate 4 Publications Verification	Cathepsin Parasite	Infection Cancer
SID 26681509 quarterhydrate is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC₅₀ of 56 nM. SID 26681509 quarterhydrate inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits *Leishmania major* with IC₅₀s of 15.4 μM and 12.5 μM, respectively. SID 26681509 quarterhydrate shows no inhibitory activity against cathepsin G .

HY-147850

JMI-346	Parasite	Infection
JMI-346 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-346 inhibits the growth of CQ ^S (3D7; IC₅₀=13 µM) and CQ ^R (RKL-9; IC₅₀=33 µM) strains of P. falciparum. JMI-346 has the potential to be used as an anti-malarial agent .

HY-134421

2-Butenoyl coenzyme A lithium	Biochemical Assay Reagents	Others
2-Butenoyl coenzyme A (lithium), an active compound, can be used as a substrate for plasmodium falciparum enyl-ACP reductases and other enyl-CoA reductases. 2-Butenoyl coenzyme A lithium can be used as a substrate analogue to study the kinetics of β-hydroxyacyl-acyl-carrier protein (ACP) dehydratase (FabZ) .

HY-147371

Quinoprazine	Parasite	Infection Neurological Disease
Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC₅₀ value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrP ^{S ^c} levels ^- .

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage .

HY-118224

BPH-715

Parasite Infection

BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC₅₀ of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells .

BPH-715	Parasite	Infection
BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC₅₀ of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells .

HY-155354

Antimalarial agent 33	Parasite	Infection
Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC₅₀ of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T_1/2=29 min). Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes .

HY-B1401

Euquinine Quinine ethyl carbonate	Others	Infection
Euquinine is an odorless salt that can be used as a substitute for quinine. Euquinine has anti-Plasmodium falciparum activity. Euquinine can be used for the study of multidrug resistance and bioavailability of Plasmodium falciparum .

HY-147849

JMI-105	Parasite	Infection
JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQ ^S (3D7; IC₅₀=8.8 µM) and CQ ^R (RKL-9; IC₅₀=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent .

HY-144296

Purine phosphoribosyltransferase-IN-2	Parasite	Infection
Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with K_is of 30, 20 and 2 nM, respectively .

HY-N8257

Dehydrobruceine A

Parasite Infection Inflammation/Immunology

Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum .
HY-100358

AQ-13 dihydrochloride

Parasite Infection

AQ-13 dihydrochloride is an aminoquinoline antimalarial agent that is effective against drug-resistant strains of Plasmodium falciparum.
HY-145233

PfPKG-IN-1

Parasite Infection

PfPKG-IN-1 is a imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).

Dehydrobruceine A	Parasite	Infection Inflammation/Immunology
Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum .

AQ-13 dihydrochloride	Parasite	Infection
AQ-13 dihydrochloride is an aminoquinoline antimalarial agent that is effective against drug-resistant strains of Plasmodium falciparum.

PfPKG-IN-1	Parasite	Infection
PfPKG-IN-1 is a imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).

HY-12651S

Primaquine-d3 diphosphate	Isotope-Labeled Compounds Parasite	Infection
Primaquine-d₃ (diphosphate) is the deuterium labeled Primaquine diphosphate. Primaquine Diphosphate (Primaquine phosphate), an 8-aminoquinoline, exerts a broad spectrum of activities against various stages of parasitic malaria. Primaquine Diphosphate remains as the only agent that destroys late hepatic stages and latent tissue forms of Plasmodium vivax and Plasmodium ovale[1][2].

HY-N4039

Homaloside D

Parasite Infection

Homaloside D is an antiplasmodial agent with an IC₅₀ of 20 μM (11 μg/mL) against Plasmodium falciparum,W₂ .

HY-N10096

Epoxyazadiradione	Parasite	Infection
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N10928

Lettowienolide

Parasite Infection

Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

HY-128204

AN3661 1 Publications Verification	Parasite	Infection
AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains (mean IC₅₀=32 nM), Ugandan field isolates (mean ex vivo IC₅₀=64 nM), and murine P. berghei and P. falciparum infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9320

13,21-Dihydroeurycomanone	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Eurycoma longifolia Jack Plants Disease Research Fields	Parasite
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii .

HY-N0352

Tuberostemonine	Infection Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields	Parasite
Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP ⁺ reductases (pfFNR) .

HY-N8383

Butyrolactone V	Infection Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Parasite
Butyrolactone V is a butanolide compound. Butyrolactone V shows antiplasmodial activity against Plasmodium falciparum K1 with an IC₅₀ of 7.9 µg/ml .

HY-N8338

Pancixanthone A	Structural Classification Flavonoids Source classification Guttiferae Garcinia vieillardii Pierre Plants Other Flavonoids	Parasite
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Structural Classification Flavonoids Xanthones Calophyllum caledonicum Vieill. ex Planch. & Triana Source classification Phenols Plants Calophyllaceae Other Flavonoids	Parasite
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-121211

Digitolutein	Morinda lucida Benth. Rubiaceae Plants	Parasite
Digitolutein is a natural product that can be isolated from the stem bark and the roots of Morinda lucida Benth. Digitolutein effectively inhibits the growth of Plasmodium falciparum with an IC₅₀ value of 12.92 μg/mL. Digitolutein can be used for the research of infection .

HY-N5109

Cheilanthifoline	Infection Alkaloids Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields	Parasite
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively .

HY-120104

Nitidanin (±)-Nitidanin	Structural Classification Buxaceae Source classification Lignans Phenylpropanoids Plants Buxus microphylla S.et Z.var. Sinica Rehd.et Wils.	Parasite HCV
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection .

HY-N8257

Dehydrobruceine A	Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields Brucea javanica (L.) Merr.	Parasite
Dehydrobruceine A is a low potent antitrypanosomal agent, with an IC₅₀ of 88.5 nM for Plasmodium falciparum .

HY-N4039

Homaloside D	Structural Classification Monophenols Source classification Phenols Plants Homalium ceylanicum (Gardn.) Benth. Salicaceae	Parasite
Homaloside D is an antiplasmodial agent with an IC₅₀ of 20 μM (11 μg/mL) against Plasmodium falciparum,W₂ .

HY-N10096

Epoxyazadiradione	Infection Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Parasite
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N10928

Lettowienolide	Quinones Structural Classification Stellaria media (L.) Villars Source classification Phenols Benzene Quinones Plants Caryophyllaceae	Parasite
Lettowienolide, a geranylbenzoquinonoid, exhibits mild in vitro activity against the Plasmodium falciparum malaria parasite (IC₅₀~20 μg/mL) .

HY-N5017

Isochondrodendrine Isochondrodendrin	Infection Alkaloids other families Classification of Application Fields Source classification Phenols Polyphenols Adiantum philippense L. Sp. Plants Isoquinoline Alkaloids Disease Research Fields	Parasite
Isochondrodendrine ( Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum .

HY-N12538

trans-Cinnamic anhydride	Structural Classification Natural Products Source classification Cinnamomum verum J. Presl Plants Lauraceae	Parasite
trans-Cinnamic anhydride is a Parasite inhibitor tnat can be isolated from Cinnamomum zeylanicum and exhibits moderate activity against Plasmodium falciparum .

HY-118494

Ascaridole	Structural Classification Natural Products Source classification Plants Dysphania ambrosioides (Linnaeus) Mosyakin & Clemants Chenopodiaceae	Parasite
Ascaridole is an anthelmintic and also has antimalarial activity .

HY-N8513

Brevicompanine B	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC₅₀ of 35 mg/mL .

HY-N3957

1-(26-Hydroxyhexacosanoyl)-glycerol	Structural Classification Natural Products Source classification Rourea minor (Gaerth.) Leenh. Plants Connaraceae	Parasite
1-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC₅₀ value of 9.48 µM for Plasmodium falciparum .

HY-N11031

Z-Antiepilepsirine	Structural Classification Alkaloids Piperidine Alkaloids Piper capense Source classification Piperaceae Plants	Parasite
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-N12151

Chaparrinone	Structural Classification Natural Products Simaroubaceae Source classification Eurycoma harmandiana Pierre Plants	Parasite
Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively) .

HY-B0770

Artemotil β-Arteether; (+)-Arteether; Arteether	Natural Products Classification of Application Fields Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	Parasite
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant Plasmodium falciparum malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-N10109A

Gallinamide A TFA	Structural Classification Natural Products Microorganisms Source classification	SARS-CoV Parasite Cathepsin
Gallinamide A TFA is a linearly depositing peptide and a potent inhibitor of cathepsin L (CatL) (IC₅₀: 17.6 pM). Gallinamide A TFA inhibits SARS-CoV-2 infection by inhibiting CatL (EC₅₀: 28 nM). Gallinamide A TFA also inhibits Plasmodium falciparum (IC₅₀: 50 nM) .

HY-N5005

Guanfu base H Atisinium chloride	Infection Alkaloids Classification of Application Fields Source classification Ranunculaceae Quinoline Alkaloids Aconitum carmichaeli Debx. Plants Disease Research Fields	Parasite
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 with IC₅₀ values of 4 μM and 3.6 μM, respectively .

HY-N3075

Phytol 1 Publications Verification (E)-Phytol	Infection Structural Classification Microorganisms Ginkgoaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Ginkgo biloba Disease Research Fields Food Research	Parasite Bacterial Keap1-Nrf2
Phytol ((E)-Phytol) is an orally active diterpenoid alcohol that can be extracted from chlorophyll. Phytol has antioxidant, anti-inflammatory, anti-schistosomiasis and antibacterial activities .

HY-N8285

Sporogen AO-1	Structural Classification Natural Products Microorganisms Source classification	Parasite
Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC₅₀ value of 1.53 μM, and also has certain cytotoxicity .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Phenols Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-N6009

8-Deoxygartanin	Infection other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	Parasite NF-κB
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM .

HY-129476

L-Canaline	Infection Structural Classification other families Classification of Application Fields Source classification Amino acids Plants Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-N7897

Myrrhone	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields	Parasite
Myrrhone is a terpenoid compound with antiplasmodial effects .

HY-N0941

beta-Mangostin 1 Publications Verification β-Mangostin	Infection Xanthones Classification of Application Fields Source classification Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Disease Research Fields Cancer	Bacterial Parasite Apoptosis
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

HY-126417

Methylenetanshinquinone	Structural Classification Natural Products Leguminosae Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	Parasite
Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .

HY-N9438

Lactucin	Iridoids Genista quadriflora Munby Source classification Plants Compositae	Apoptosis Parasite
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities .

HY-N6742

Borrelidin 1 Publications Verification Treponemycin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Anti-parasitic Antibacterial Disease Research Disease Research Fields	CDK Parasite Apoptosis Antibiotic
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC₅₀ of 24 μM . Borrelidin is a potent angiogenesis inhibitor, with an IC₅₀ of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells . Borrelidin has strong antimalarial activities, with IC₅₀s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively .

Species:	Human (1)
Tag:	His (4) SUMO (1)
Source:	E. coli Cell-free (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P700380

	ACKR1 Protein, Human (Cell-Free, His) ACKR1; atypical chemokine receptor 1 (Duffy blood group); DARC; Duffy blood group, chemokine receptor; Duffy blood group , FY; Duffy antigen/chemokine receptor; CCBP1; CD234; Dfy; GPD; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; FY; GpFy; WBCQ1	Human	E. coli Cell-free
	ACKR3, an atypical chemokine receptor, modulates chemokine levels and localization by high-affinity binding, inducing sequestration, degradation, or transcytosis. Also known as a chemokine interceptor or decoy receptor, ACKR3 binds to chemokines like CXCL11 and CXCL12/SDF1. Unlike conventional signaling, ACKR3 triggers beta-arrestin recruitment, leading to ligand internalization and MAPK pathway activation. In interneurons, it regulates CXCR4 levels, adapting chemokine responsiveness. In glioma cells, it activates the MEK/ERK pathway, influencing growth and survival. While inactive in normal hematopoietic cells, ACKR3, activated by CXCL11 in malignant cells, enhances cell adhesion, migration, and acts as an HIV coreceptor. ACKR1 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR1 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of ACKR1 Protein, Human (Cell-Free, His) is 336 a.a., with molecular weight of 41.1 kDa.

HY-P702432

	*SEY1 Protein, Plasmodium* knowlesi (Cell-Free, His)** Protein SEY1 homolog	Others	E. coli Cell-free
	The SEY1 protein may be a GTP-binding protein that is critical for the structural integrity of the tubular endoplasmic reticulum network. Its role is suggested to play a key role in the formation and stability of this cellular compartment, contributing to its overall structure and function. SEY1 Protein, Plasmodium knowlesi (Cell-Free, His) is the recombinant SEY1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SEY1 Protein, Plasmodium knowlesi (Cell-Free, His) is 883 a.a., with molecular weight of 103.5 kDa.

HY-P702363

Major facilitator superfamily domain-containing Protein, Plasmodium berghei (Cell-Free, His)

Uncharacterized protein
Others E. coli Cell-free
HY-P702364

Major facilitator superfamily domain-containing Protein, Plasmodium berghei (Cell-Free, His, SUMO)

Uncharacterized protein
Others E. coli Cell-free

Cat. No.	Product Name	Chemical Structure

HY-B0439S1

Sulfadoxine D3

Sulfadoxine-d₃ is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].