1. Metabolic Enzyme/Protease
    Anti-infection
  2. Dihydroorotate Dehydrogenase
    Parasite
  3. PfDHODH-IN-2

PfDHODH-IN-2 

Cat. No.: HY-W078844
Handling Instructions

PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria.

For research use only. We do not sell to patients.

PfDHODH-IN-2 Chemical Structure

PfDHODH-IN-2 Chemical Structure

CAS No. : 425629-94-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PfDHODH-IN-2, a dihydrothiophenone derivative (Compound 11), is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor with an IC50 of 1.11 µM. PfDHODH-IN-2 acts as an antimalarial agent and can be used for the research of malaria[1].

IC50 & Target

IC50: 1.113 µM (PfDHODH)
IC50: >50 µM ( hDHODH)[1]

In Vitro

Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality[1].
PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC50=1.113 µM) over hDHODH (IC50>50 µM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 values of both >20 µM, respectively in whole cell assays[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.76

Formula

C₁₃H₁₂ClNO₃S

CAS No.

425629-94-3

SMILES

O=C(C1=C(NC2=CC=C(Cl)C=C2)SCC1=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (41.98 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3584 mL 16.7920 mL 33.5841 mL
5 mM 0.6717 mL 3.3584 mL 6.7168 mL
10 mM 0.3358 mL 1.6792 mL 3.3584 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1.25 mg/mL (4.20 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1.25 mg/mL (4.20 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (4.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PfDHODH-IN-2Dihydroorotate DehydrogenaseParasiteDHODHPlasmodium falciparumPfDHODH3D7malariaparasitedihydrothiophenonederivativeInhibitorinhibitorinhibit

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Product Name:
PfDHODH-IN-2
Cat. No.:
HY-W078844
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